Psychopharmacology
October 5, 2026
Jingqi Xu, Adrien Nette, Christina Zakala et al.
Cannabis and tobacco are widely used substances with addiction potential, which have opposing effects on cognition and subjective experience and are often co-used in a single occasion. The purpose of this systematic review was to synthesize evidence of the acute effects of same-occasion co-use of cannabis and tobacco. Databases Embase, Medline, CINAHL, PsycINFO, and Web of Science were searched...
Medical Journal of Dr. D.Y. Patil Vidyapeeth
October 1, 2026
Nikhar Satyapal, Parisha Kelkar, Abhimanyu Sinha et al.
A BSTRACT Cannabis is the most widely used illicit psychoactive substance worldwide. While cannabis-related psychosis is well documented, cannabis-associated mania is a relatively under-recognized clinical entity that poses diagnostic and therapeutic challenges. We describe three young adult males who presented with first-episode mania following a recent escalation of cannabis consumption. All...
Journal of Addictive Diseases
September 30, 2026
Rocco Miazzi, Clara Cestonaro, Claudio Terranova
BACKGROUND Adolescence represents a vulnerable developmental period during which cannabis exposure may be associated with psychological, neuropsychological, and neurobiological alterations. OBJECTIVE This structured review examines the psychological and neuropsychological effects associated with cannabis use during adolescence, focusing exclusively on human studies. METHODS A structured...
The Journal of Clinical Psychiatry
September 28, 2026
Justine Perino, Amélie Daveluy, Anna Truong-Bastos et al.
Objective: Psychiatric disorders are frequently associated with drug use and substance use disorders (SUDs). This study aimed to (1) assess the risk of psychiatric readmission associated with cannabis use in young adults (18-29 years) with bipolar or psychotic disorders and (2) describe drug use and SUD recorded in their medical files. Methods: This historical cohort included 200 adults aged...
Zenodo (CERN European Organization for Nuclear Research)
September 22, 2026
Paul Michael Hallelujah
preprint
This preprint explores the hypothesis that a significant proportion of modern schizophrenia diagnoses among youth may be a diagnostic artifact resulting from prohibition era policies and the consumption of highly potent adulterated cannabis. By synthesizing historical psychiatric literature, epidemiological data from Denmark and Canada, and neurobiological research on the endocannabinoid...
Journal of Forensic Sciences
September 16, 2026
Laura A. Ciolino, Tracy L. Ranieri
Abstract: Synthetically derived tetrahydrocannabinol (THC) products, including vaping liquids and edibles, are widely available in the US. Serious adverse events associated with the use of THC products are reported in large‐scale studies for both adults and children and include intoxication, psychosis, encephalopathy, CNS depression, respiratory failure, and acute cardiovascular emergencies....
European Journal of Pharmacology
September 15, 2026
Anna Brancato, Martina Cicero, Valentina Castelli et al.
Stress is a major determinant of psychopathology, with coping and cognitive impairment arising from abnormal glucocorticoid activity and brain-derived neurotrophic factor (BDNF)-dependent neuroplasticity in the hippocampus. The endocannabinoid system modulates stress and hippocampal functioning since early development, thus its early-life disruption may program vulnerability to stress-related...
Neuropsychopharmacology
September 15, 2026
Alexandra Gaillard, Daniel J Fehring, Philip J Sumner et al.
Chronic cannabis use drives neuroadaptations in reward and stress-related circuits that condition the brain to the drug and its associated cues. These changes underlie craving and heighten its sensitivity to cue- and stress-induced triggers, sustaining drug intake and promoting relapse. Task-based functional magnetic resonance imaging of drug cue reactivity paradigms has shown the dorsolateral...
Journal of Cognitive Enhancement
September 14, 2026
Katherine Harrison, Jessica Halverson, Tina Ozbeki et al.
Abstract Despite substantial efforts to understand the impact of cannabis use on cognition, the potential effects remain debated. More research focusing on how cannabis is used, specifically around the quantity used and cannabis co-use with other substances, is needed to better understand the outcomes of cannabis use. Current cannabis users were asked to report all substance use history and...
The Canadian Journal of Psychiatry
September 11, 2026
James Mirabelli, James MacKillop, David Streiner et al.
Background Individuals with borderline personality disorder (BPD) frequently use cannabis, often for self-medication. However, cannabis use has also been linked to BPD symptom severity, suggesting heterogeneity in its effects. Individuals with BPD frequently experience psychotic-like symptoms and may demonstrate elevated psychosis vulnerability, which is associated with greater symptom severity...