The Canadian Journal of Psychiatry
September 11, 2026
James Mirabelli, James MacKillop, David Streiner et al.
Background Individuals with borderline personality disorder (BPD) frequently use cannabis, often for self-medication. However, cannabis use has also been linked to BPD symptom severity, suggesting heterogeneity in its effects. Individuals with BPD frequently experience psychotic-like symptoms and may demonstrate elevated psychosis vulnerability, which is associated with greater symptom severity...
medRxiv
June 1, 2026
Erica J. Li, Basmah Mosharraf, Hiba Ali et al.
Background: Psychedelics are emerging as potential management options for chronic musculoskeletal pain due to preliminary evidence of effectiveness and low addictive potential, but patients’ perceptions remain unknown. This study assessed patient perceptions regarding psilocybin for musculoskeletal pain. Methods: We conducted a cross-sectional survey of adults (≥19) with musculoskeletal pain...
The American journal of psychiatry
February 1, 2026
Jane Metrik, Elizabeth R Aston, Rachel L Gunn et al.
Cannabis use is strongly linked with heavy drinking and worse alcohol treatment outcomes; however, it may also contribute to decreased alcohol consumption. To date, no human studies have established a causal effect of cannabis on alcohol motivation. The aim of this double-blind crossover randomized clinical trial was to examine dose-dependent acute effects of delta-9-tetrahydrocannabinol (THC)...
Cannabis
November 26, 2024
Anna Marie Froude, Nikki Pangborn, Phillip Britz-McKibbin et al.
Although Canada legalized cannabis beverages in 2019, most available research on acute cannabis intoxication derives from dried flower and edible products. The distinct bioavailability and pharmacokinetic properties of phytocannabinoids ingested from beverages, however, contribute to significantly different acute and long-term effects that need to be better understood to ensure consumer safety....
Journal of Psychopharmacology
August 13, 2024
Kim Madden, Breanne Flood, Darren Young Shing et al.
13 citations
Background: Psychedelic drugs have been of interest in medicine since the early 1950s. There has recently been a resurgence of interest in psychedelics. Aims: The objective of this study is to determine the extent of the available literature on psilocybin for medical indications including the designs used, study characteristics, indications studied, doses, and authors’ conclusions. We identify...