Drug and Alcohol Dependence
September 1, 2026
S. Vanegas, J. Marusich, J. Maturano et al.
BACKGROUND AND PURPOSE Cannabinoids, including Δ9-tetrahydrocannabinol (THC) and synthetic CB1 agonists elicit acute psychotropic effects that undergo tolerance with repeated exposure. In contrast, the effects of prolonged cannabinol (CBN) use are unknown. This study examined (1) the effects of repeated CBN administration on classic cannabimimetic outcomes, (2) whether these effects undergo...
Psychopharmacology
September 1, 2026
Renée Martin-Willett, Samantha N. Melendez, Kent E. Hutchison et al.
RATIONALE An estimated two-thirds of medical cannabis users in the United States are motivated by chronic pain, but clinical guidance remains guarded as to whether the potential benefit of cannabinoids for pain outweighs potential risks, such as effects on cognition. OBJECTIVES In a study where participants experienced benefits of cannabinoids for pain and tension, we evaluated cannabis effects...
Perspectives on Science and Christian Faith
September 1, 2026
Yong Fang Zhu, Kyra White
With the legalization of cannabis and the proliferation of products containing its main psychoactive component, tetrahydrocannabinol (THC), the use of cannabis-associated psychoactive substances has moved from the margins to the mainstream and, in the case of recreational marijuana, involves products of increasing potency. This development raises several specific interdisciplinary questions,...
Current Neuropharmacology
August 31, 2026
Harrison J. Elder, Bryan W. Jenkins, C. Austin Zamarripa et al.
Introduction: This narrative review systematically examines the available empirical evidence for interactions between delta-9-tetrahydrocannabinol (Δ9-THC or THC) and C. sativa’s other phytochemical constituents hypothesized to underpin the popular yet controversial notion of ‘entourage effects’ experienced with botanical cannabis. Many relevant preclinical and clinical studies have been...
Nursing Edição Brasileira
August 27, 2026
O uso de Cannabis sativa tem crescido globalmente, acompanhado por um aumento significativo na concentração de delta-9-tetrahidrocanabinol (THC) nos produtos disponíveis no mercado. Esta revisão sistemática teve como objetivo analisar a associação entre a exposição a altas concentrações de THC, a precocidade no início do uso e o desenvolvimento de quadros psicóticos. A literatura demonstra uma...
Psychopharmacology
August 27, 2026
Frederick S. Barrett, David Wolinsky, Zach Daily et al.
RATIONALE: Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. OBJECTIVES: This brief report presents preliminary findings from a pilot human laboratory study that directly compared the acute...
Journal of Cannabis Research
August 26, 2026
Ario Safaeian, Kaylen M. Young, John G. Howland et al.
Abstract Background Cannabis use has increased in recent years due to legalization. Smoking cannabis leads to inhalation of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in addition to other particles and gas in the smoke matrix as a result of combustion. The effect of THC on breathing pattern and metabolism has been characterized, but the influence of CBD and the smoke matrix on...
BJPsych Open
August 25, 2026
Edward Chesney, Millie Lloyd, Sébastien Brodeur et al.
BACKGROUND: Cannabis use is common in people with psychosis and is associated with poor outcomes. AIMS: To assess insight into cannabis use disorder, perceptions about how cannabis use influences mental health and the desire to change cannabis use among people with psychotic disorders. METHOD: Adults with a psychotic disorder and comorbid cannabis use disorder were asked about the impact of...
Neuropsychopharmacology
August 22, 2026
Carrie Cuttler, Matteya A Proctor, Nicholas C. Glodosky et al.
People who use cannabis commonly report stress-relieving effects, yet no studies have simultaneously assessed the acute effects of cannabis on multiple stress systems under placebo-controlled conditions. We conducted a randomized, double-blind, placebo-controlled trial in which 120 people (56 men, 52 women, 12 non-binary/transgender) who regularly use cannabis were assigned to vape placebo, a...
Molecular Neurobiology
August 20, 2026
Oleh Durydivka, Ondřej Florián, Petr Palivec et al.
Minor cannabinoids and semisynthetic cannabis constituents, such as derivatives of tetrahydrocannabinol (THC) and hexahydrocannabinol (HHC), are increasingly encountered in consumer products, yet their signaling profiles at cannabinoid receptors remain incompletely characterized. Here, we describe how structural modifications of THC and HHC, including variations in alkyl side-chain length...