Brain, Behavior, and Immunity
May 1, 2026
Havilah P. Ravula, Barkha J. Yadav-Samudrala, Laith E. Sawaqed et al.
Δ9-tetrahydrocannabinol (THC) has been studied for its neuroprotective benefits in disease and its ability to improve HIV-1-related symptoms in clinical and preclinical models. Chronic THC administration may cause reduced sensitivity to antinociceptive, hypothermic, and anxiolytic effects following acute THC administration, and HIV status may further influence these effects. Thus, the present...
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
May 1, 2026
Zachary Anderson, Matthew Gunn, Emily Jones et al.
Cannabis use among young adults has reached the highest levels ever recorded. Evidence indicates that acute Δ9-tetrahydrocannabinol (THC) disrupts brain connectivity. Few studies have examined this on a whole-brain level. We examined the effects of a single moderate dose of THC on resting-state functional brain networks among young adult cannabis users. In a within-subject, double-blind,...
Sleep
May 1, 2026
Denise C. Vidot, Bria-Necole Diggs, Amrit Baral et al.
Abstract Introduction Psychedelic use and interest in its therapeutic potential are rapidly increasing; yet its relationship with insomnia remains poorly understood. This study aims to estimate differences in insomnia severity by type of psychedelic consumed among a cohort of 18-to-35-year olds. Methods Data are from the Herbal Heart Study - Sleep Ancillary (N=100) cannabis consumers....
Journal of Analytical Toxicology
April 30, 2026
Alexandria S. Senetra, Sushobhan Mukhopadhyay, Yi-Hua Chiang et al.
Delta-8-tetrahydrocannabinol (Δ8THC) has been growing in popularity across the United States due to its reported therapeutic benefits, including pain relief, euphoria, relaxation, and mild psychoactive effects, especially in areas where sale of delta-9-tetrahydrocannabinol (Δ9THC) is illegal. Currently, much debate surrounds Δ8THC regarding its regulatory status and whether this compound is...
Frontiers in Psychiatry
April 27, 2026
Valerio Ricci, Alessandro Sarni, Domenico de Berardis et al.
Background and hypothesis Cannabis use initiation during adolescence has increased globally, raising concerns about neurodevelopmental consequences during this critical period when the brain undergoes extensive remodeling in cannabinoid receptor-rich regions. Study design This systematic review examines neurodevelopmental consequences of adolescent cannabis use, focusing on structural brain...
Translational Psychiatry
April 23, 2026
Jimmy Olusakin, Mahima Dewan, A. Kashyap et al.
Cannabis use during pregnancy is increasing, often to alleviate stress and anxiety, yet the impact of prenatal cannabis exposure alone, or in combination with psychosocial stress on maternal regulation and downstream offspring neurodevelopment remains unclear. Here, we developed a translational rodent model combining prenatal Δ⁹-tetrahydrocannabinol (THC) exposure with chronic psychosocial...
Psychopharmacology
April 23, 2026
Josephine Sena Lumor, Henriette Nyberg, Elisabeth Nerem et al.
Abstract Rationale As cannabis legalization and decriminalization have expanded, it is increasingly perceived as a low-risk substance. Concurrently, the potency of cannabis products and the number of young adults seeking treatment for cannabis use disorder have risen markedly. A growing body of research links early onset, frequent use, and high potency cannabis products to a range of adverse...
medRxiv Preprint Server
April 23, 2026
Giada Lombardi, Grace Blest‐hopley, Martina Maria Tarantini et al.
preprint
Regular cannabis use has been associated with alterations in reward-related neural processes, yet findings remain inconsistent and the relationship between neural activity and behavioural performance is not fully understood. The present study aimed to characterise neural and behavioural correlates of reward processing in regular cannabis users (CU) compared with matched non-users (NU) using the...
Journal of ethnicity in substance abuse
April 22, 2026
Naseem Abdulmohi Alhujaili, O. Ayonrinde
Cannabis use has long been linked to the emergence and worsening of psychotic disorders, particularly among adolescents and young adults. This study aimed to determine the prevalence of cannabis use and its psychiatric associations in youth and young adults enrolled in an Early Psychosis Intervention (EPI) program in Southeast Ontario. A retrospective cross-sectional analysis was conducted on...
Cancer causes & control : CCC
April 22, 2026
Amrit Baral, Yue Pan, Wayway M. Hlaing et al.
To examine the prevalence of lifetime ("ever") cannabis and classic psychedelic use, and their co-use among U.S. adults aged ≥ 50 years with versus without a lifetime history of cancer, and to describe variation by cancer type/site among survivors. We analyzed pooled 2015-2019 and 2021-2022 National Survey on Drug Use and Health (NSDUH) data of U.S. adults aged ≥ 50 years (Unweighted; n =...