Neuropsychopharmacology
August 22, 2026
Carrie Cuttler, Matteya A Proctor, Nicholas C. Glodosky et al.
People who use cannabis commonly report stress-relieving effects, yet no studies have simultaneously assessed the acute effects of cannabis on multiple stress systems under placebo-controlled conditions. We conducted a randomized, double-blind, placebo-controlled trial in which 120 people (56 men, 52 women, 12 non-binary/transgender) who regularly use cannabis were assigned to vape placebo, a...
Journal of Psychopharmacology
March 1, 2026
Carrie Cuttler, Ryan J Mclaughlin
One of the most robust acute effects of cannabis is impaired memory. Although memory is not a unitary construct, most cannabis research has focused on verbal memory. Less is known about its effects on more ecologically valid domains of memory, such as prospective and temporal order memory. We conducted a randomized, double-blind, placebo-controlled study to map out which aspects of memory are...
Proceedings of the National Academy of Sciences
December 30, 2025
Catherine Hume, Carrie Cuttler, Samantha L Baglot et al.
With approximately 4% of the world's population using cannabis, there is a need to better understand its physiological effects. Cannabis consumption acutely promotes food intake ("the munchies") via delta-9-tetrahydrocannabinol-mediated activation of cannabinoid 1 receptors (CB1R); however, these appetitive effects have not been well characterized. We examined effects of cannabis vapor...
Cannabis and Cannabinoid Research
December 1, 2025
Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al.
2 citations
The legalization of cannabis in several states across the United States has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Previous rodent studies have revealed age and sex differences in response to injected Δ9-tetrahydrocannabinol (THC). However, the pharmacokinetic and pharmacodynamic properties of THC administered...
Cannabis and Cannabinoid Research
January 8, 2024
Timothy G. Freels, Sara R Westbrook, Erica Zamberletti et al.
Introduction: Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that cannabis use among adolescents could increase dramatically in the coming years. Historically, it has been difficult to model real-world cannabis use to investigate the causal relationship between cannabis use in adolescence and...
bioRxiv : the preprint server for biology
January 22, 2023
Timothy G. Freels, Sara R Westbrook, Hayden R Wright et al.
preprint
Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that cannabis use among adolescents could increase dramatically in the coming years. Historically, it has been difficult to model real-world cannabis use to investigate the causal relationship between cannabis use in adolescence and behavioral and...
Scientific Reports
December 14, 2021
Samantha L Baglot, Catherine Hume, Gavin N Petrie et al.
Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are critical to study the impact of cannabis on brain and behaviour. Most animal studies to date utilize injection of delta-9-tetrahydrocannabinol (THC; primary psychoactive component of cannabis). THC injections produce markedly different...
Journal of Affective Disorders
August 1, 2018
Carrie Cuttler, Alexander Spradlin, Ryan J Mclaughlin
Cannabis is commonly used to alleviate symptoms of negative affect. However, a paucity of research has examined the acute effects of cannabis on negative affect in everyday life. The current study provides a naturalistic account of perceived changes in symptoms of depression, anxiety, and stress as a function of dose and concentration of Δ9tetrahydrocannabinol (THC) and cannabidiol (CBD). Data...
Drug and Alcohol Dependence
December 1, 2017
Amy T Nusbaum, Paul Whitney, Carrie Cuttler et al.
Cannabis use has increased rapidly in recent decades. The increase in cannabis use makes it important to understand the potential influence of chronic use on attentional control and other executive functions (EFs). Because cannabis is often used to reduce stress, and because stress can constrain attentional control and EFs, the primary goal of this study was to determine the joint effect of...
Pharmacological Research
November 2016
Danilo de Gregorio, Luca Posa, Rafael Ochoa-Sanchez et al.
d-lysergic diethylamide (LSD) is a hallucinogenic drug that interacts with the serotonin (5-HT) system binding to 5-HT1 and 5-HT2 receptors. Little is known about its potential interactions with the dopamine (DA) neurons of the ventral tegmental area (VTA). Using in-vivo electrophysiology in male adult rats, we evaluated the effects of cumulative doses of LSD on VTA DA neuronal activity,...
Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al.
preprint
Abstract The legalization of cannabis in several states across the US has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Rodent models are particularly valuable in this respect because they provide precise control over external variables. Previous rodent studies have found age and sex differences in response to...