Behavioral Sciences
April 20, 2026
Jeffrey Alan Gibbons, Chayse Angela Cotton, Matthew Traversa et al.
The fading affect bias (FAB) is the faster fading of unpleasant than pleasant affect, and this effect is positively and negatively related to healthy/adaptive and unhealthy/non-adaptive outcomes, respectively. Research has argued that the FAB makes people happy and it prompts them to seek out pleasant experiences. Although Pillersdorf and Scoboria found a negative relation between the FAB and...
Journal of Neuroinflammation
April 17, 2026
Mary K Ford, Peter W Halcrow, Anna E Laird et al.
Chronic neuroinflammation is associated with comorbidities in people with HIV (PWH) on antiretroviral therapy (ART). While cannabis use is associated with reduced neuroinflammation and neurocognitive impairment (NCI) in PWH, the underlying mechanisms are unknown. To address this gap in knowledge, we analyzed monocyte-derived macrophages (MDMs) from a cohort of 50 PWH and 33 people without HIV...
Frontiers in Behavioral Neuroscience
April 16, 2026
Chen Hanna Ryder, Carmit Gal, Einav Levy et al.
Introduction With expanding global cannabis legalization and rising usage rates, elucidating the specific neurocognitive impact of acute cannabis intoxication across biological sexes is critical. Methods Using a 2 × 2 factorial design, we examined 154 adults: 77 individuals who use cannabis regularly (≥ 5 days/week for ≥ 1 year; 46 males, 31 females) and 77 matched controls (32 males, 45...
Psychopharmacology
April 15, 2026
Hanna Molla, Evan Hahn, Christian Ramos et al.
Abstract Rationale Many cannabis users claim that one reason they use cannabis is to relieve stress or dampen effects of stressful memories. However, the processes by which cannabis or its primary constituent, Δ 9 -tetrahydrocannabinol (THC) alleviate stressful experiences remains unclear. Objective Here, we assessed whether low oral doses of THC reduce emotional or physiological responses to...
Acta Psychiatrica Scandinavica
April 8, 2026
Antti Mustonen, Solja Niemelä, Alexander Denissoff et al.
Research indicates that first‐episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis‐related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis‐induced psychosis (CIP) in comparison with FEP without substance use disorder (SUD).
Journal of Australian studies
April 3, 2026
Clare J. Burnett
ABSTRACT In 1868 eminent Australian author Marcus Clarke wrote a gothic tale for his own Colonial Monthly Magazine titled “Cannabis Indica”, purportedly under the influence of hashish. Contemporaneous reviewers discussed this little-known short story as merely a curio, and modern scholars have followed suit. However, the experimental short story is distinguished as one of the first fictional...
Cannabis and Cannabinoid Research
April 2026
Conor H. Murray, Joshua Cassarino, Ziva D. Cooper
The effect of cannabis use on health is likely to depend on individual differences. In particular, there is a growing need to understand the impact of cannabis and delta-9-tetrahydrocannabinol (THC) on brain and behavioral health across the lifespan. We conducted a narrative review summarizing the effects of cannabis and THC across three stages of life: in utero, adolescence, and late...
Drug and Alcohol Dependence
April 1, 2026
Che Liu, Janna Cousijn, Emese Kroon et al.
Although behavioral and epidemiological studies demonstrate high co-morbidity between cannabis use and depression, the underlying neurobiological mechanisms of this relationship remain poorly understood. This study evaluated the interaction between cannabis use and depression on brain resting state functional connectivity using graph theory network properties in 223 individuals who currently...
The International Journal of Neuropsychopharmacology
April 1, 2026
Mary M Torregrossa, Tamara Racic, S. Baglot et al.
Abstract Background Most substance users are polysubstance users; however, little is known about how the combined use of different drugs affects the course of substance use disorder or effectiveness of treatment. Notably, co-use of cannabis and nicotine is very common, and we previously demonstrated that nicotine enhances the self-administration of a synthetic cannabinoid receptor agonist and...
Asian Journal of Psychiatry
April 1, 2026
Valerio Ricci, Alessandro Sarni, Marialuigia Barresi et al.
BACKGROUND Cannabis-induced psychotic disorders represent 12-35% of first-episode psychosis presentations globally. Traditional clinical wisdom holds these conditions carry favorable prognosis based on rapid symptomatic improvement, yet this narrative rests almost exclusively on symptomatic outcomes, overlooking functional, cognitive, and subjective recovery dimensions. OBJECTIVE To...