Neuroreport
November 16, 2001
Ros R Brett, F MacKenzie, Judith A Pratt
The effects of Delta9-tetrahydrocannabinol (THC) on neural activity in the rat were investigated using [14C]2-deoxyglucose autoradiography to measure local cerebral glucose use. Overall, THC reduced glucose use at 5 mg/kg and slightly increased it at 1 mg/kg. Significant reductions were seen at the higher dose in regions of the hippocampus and limbic system, and in structures associated with...
Neuropsychopharmacology
November 2001
Carl L. Hart, W Van Gorp, Margaret Haney et al.
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not been adequately assessed under experimental conditions. In the present study, we used a within-participant double-blind design to evaluate the effects acute marijuana smoking on complex cognitive performance in...
Addiction
November 1, 2001
Mitch Earleywine
57 citations
AIMS: Koro, an acute panic reaction related to the perception of penile retraction, was once considered limited to specific cultures. The disorder has appeared as part of a panic response to cannabis, but only in citizens of India. This study looked for cannabis-induced Koro in Americans. DESIGN: Given the relative rarity of cannabis-induced Koro, this work focused on individual case studies....
Archives of General Psychiatry
October 2001
A J Budney, J R Hughes, B A Moore et al.
Although withdrawal symptoms are commonly reported by persons seeking treatment for marijuana dependence, the validity and clinical significance of a marijuana withdrawal syndrome has not been established. This controlled outpatient study examined the reliability and specificity of the abstinence effects that occur when daily marijuana users abruptly stop smoking marijuana. Twelve daily...
Psychopharmacology
August 2001
Torbjörn U C Järbe, R J Lamb, S Lin et al.
(R)-methanandamide (AM-356), a metabolically more stable chiral analog of the endocannabinoid ligand anandamide, was used as a representative of fatty acid ethanolamide CB1 receptor ligands to characterize the discriminative stimulus functions of anandamides. Rats discriminated between 10 mg/kg (R)-methanandamide and vehicle administered IP 15 min prior to session onset. Another group of rats...
Fortschritte der Neurologie · Psychiatrie
August 1, 2001
J Schlimme, D Rada, Udo Schneider
Cannabis consumption is a social and cultural phenomenon. It has a specific place in each society, therefore psychotropic effects are judged differently. In medieval Islam cannabis consumption showed connections with religious and mystic events and was basically formed through consuming sufis. The main risk of cannabis use was especially the induction of "madness" or psychotic states in case of...
Drug and Alcohol Dependence
July 1, 2001
Aron H Lichtman, Justin L. Poklis, Alphonse Poklis et al.
Although the majority of cannabinoid users smoke marijuana, the preponderance of laboratory animal research is based on administration of Delta9-tetrahydrocannabinol (Delta9-THC) or other cannabinoid agents via injection. The aim of the present study was to evaluate the impact of inhaling marijuana, or ethanol-extracted placebo smoke in the mouse model of cannabinoid activity by assessing...
Neuropharmacology
July 1, 2001
S Lamarque, K Taghzouti, H Simon
Cannabis sativa preparations are some of the most widely used illicit recreational drugs. In addition to their direct addictive potential, cannabinoids may influence the sensitivity to other drugs. The aim of the present study was to determine if a cross-sensitization between Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and other drugs (amphetamine and heroin) could be demonstrated. We examined...
European Journal of Neuroscience
February 2001
S C Azad, Giovanni Marsicano, I Eberlein et al.
This study investigated whether the nitric oxide pathway was involved in the central effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive constituent of cannabis sativa. Body temperature, nociception and locomotion were measured in neuronal nitric oxide synthase (nNOS) knock-out (KO) mice and wild-type (WT) controls after intraperitoneal application of Delta(9)-THC....
The British Journal of Psychiatry
February 1, 2001
Andrew Johns
474 citations
BACKGROUND: Cannabis is commonly regarded as an innocuous drug and the prevalence of lifetime and regular use has increased in most developed countries. However, accumulative evidence highlights the risks of dependence and other adverse effects, particularly among people with pre-existing psychiatric disorders. AIMS: To re-evaluate the adverse effects of cannabis in the general population and...