Nature Communications
December 9, 2025
Cristina Martín-Monteagudo, Javier Sánchez Romero, Julia Adams et al.
Cannabis is the most widely used illicit drug, particularly during adolescence. Its consumption disrupts glutamate homeostasis and synaptic plasticity in the nucleus accumbens (NAc). Here, we identify a functionally distinct accumbal astrocytic ensemble, associated with the ventral hippocampus-NAc (vHip→NAc) circuit, that is critical for tetrahydrocannabinol (THC)-induced synaptic and...
Nature Medicine
June 2023
Margaret Haney, Monique Vallée, Sandy Fabre et al.
Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, is a signaling-specific inhibitor of the cannabinoid receptor 1 (CB1-SSi). AEF0117 selectively inhibits a subset of intracellular effects resulting from Δ9-tetrahydrocannabinol (THC) binding without modifying behavior per se. In mice and...
Autophagy
December 2020
Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras et al.
The recreational and medical use of cannabis is largely increasing worldwide. Cannabis use, however, can cause adverse side effects, so conducting innovative studies aimed to understand and potentially reduce cannabis-evoked harms is important. Previous research conducted on cultured neural cells had supported that CNR1/CB1R (cannabinoid receptor 1), the main molecular target of cannabis,...
Nature
July 2020
Daniel Jimenez-Blasco, Arnau Busquets-García, Etienne Hebert-Chatelain et al.
Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses1-5. By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors5-7. However, whether the activation of astroglial receptors can directly regulate cellular glucose metabolism to eventually modulate behavioural responses is...
Neuropsychopharmacology
June 2013
Emma Puighermanal, Arnau Busquets-García, Maria Gomis-Gonzalez et al.
The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects of delta9-tetrahydrocannabinol (THC) were prevented by the subchronic inhibition of the mammalian target of rapamycin (mTOR) pathway. In the present study, we assess the...
PLoS Biology
October 2007
Krisztina Monory, Heike Blaudzun, Federico Massa et al.
Marijuana and its main psychotropic ingredient Delta(9)-tetrahydrocannabinol (THC) exert a plethora of psychoactive effects through the activation of the neuronal cannabinoid receptor type 1 (CB1), which is expressed by different neuronal subpopulations in the central nervous system. The exact neuroanatomical substrates underlying each effect of THC are, however, not known. We tested locomotor,...
European Journal of Neuroscience
February 2001
S C Azad, Giovanni Marsicano, I Eberlein et al.
This study investigated whether the nitric oxide pathway was involved in the central effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive constituent of cannabis sativa. Body temperature, nociception and locomotion were measured in neuronal nitric oxide synthase (nNOS) knock-out (KO) mice and wild-type (WT) controls after intraperitoneal application of Delta(9)-THC....
Marta Navarrete, Cristina Martín-Monteagudo, Nagore Puente et al.
preprint
Abstract Cannabis is the most widely used illicit drug, particularly during adolescence, and its consumption disrupts glutamate homeostasis and synaptic plasticity in the nucleus accumbens (NAc). While astrocytic cannabinoid receptors (CB1Rs) are known to modulate synaptic plasticity and behavior, the extent to which specific astrocytic ensembles drive tetrahydrocannabinol (THC)-induced...