Neuropharmacology
November 1, 2018
Elias Dakwar, Edward V. Nunes, Carl L. Hart et al.
83 citations
Efforts to translate sub-anesthetic ketamine infusions into widespread clinical use have centered around developing medications with comparable neurobiological activity, but with attenuated psychoactive effects so as to minimize the risk of behavioral toxicity and abuse liability. Converging lines of research, however, suggest that some of the psychoactive effects of sub-anesthetic ketamine may...
Drug and Alcohol Dependence
September 1, 2017
Diana R Keith, Erik W. Gunderson, Margaret Haney et al.
Individuals who work nonstandard schedules, such as rotating or night shifts, are more susceptible to workplace injuries, performance decrements, and reduced productivity. This population is also almost twice as likely to use illicit drugs as individuals working a standard day shift. The purpose of this study was to examine the effects of smoked marijuana on performance, mood, and sleep during...
Current Psychiatry Reports
February 1, 2016
Charles Ksir, Carl L. Hart
Interest in the relationship between cannabis use and psychosis has increased dramatically in recent years, in part because of concerns related to the growing availability of cannabis and potential risks to health and human functioning. There now exists a plethora of scientific articles addressing this issue, but few provide a clear verdict about the causal nature of the cannabis-psychosis...
Drug and Alcohol Dependence
January 15, 2014
Elias Dakwar, C. Anerella, Carl L. Hart et al.
125 citations
Background Sub-anesthetic ketamine infusions may benefit a variety of psychiatric disorders, including addiction. Though ketamine engenders transient alterations in consciousness, it is not known whether these alterations influence efficacy. This analysis evaluates the mystical-type effects of ketamine, which may have therapeutic potential according to prior research, and assesses whether these...
Biological Psychiatry
September 12, 2013
Elias Dakwar, Frances R. Levin, Richard W Foltin et al.
Background: Cocaine dependence involves problematic neuroadaptations that might be responsive to modulation of glutamatergic circuits. This investigation examined the effects of subanesthetic ketamine infusions on motivation for quitting cocaine and on cue-induced craving in cocaine-dependent participants, 24 hours postinfusion. Methods: Eight volunteers with active DSM-IV cocaine dependence...
Pharmacology, Biochemistry, and Behavior
September 2010
Carl L. Hart, Aaron B Ilan, Alan Gevins et al.
Previously, we reported that acute marijuana intoxication minimally affected complex cognitive performance of daily marijuana smokers. It is possible that the cognitive tests used were insensitive to marijuana-related cognitive effects. In the current study, electroencephalographic (EEG) signals were recorded as daily marijuana users performed additional tests of immediate working memory and...
Psychopharmacology
January 2003
Margaret Haney, Carl L. Hart, Amie S Ward et al.
Symptoms of marijuana withdrawal include increased irritability, depression and anxiety, and decreased sleep quality. Nefazodone, which is an antidepressant with sedative properties, may attenuate symptoms of marijuana withdrawal. The present within-subject, placebo-controlled study investigated the effects of nefazodone during marijuana withdrawal. Marijuana smokers [ n=7; averaging 6.0...
Drug and Alcohol Dependence
August 1, 2002
Carl L. Hart, Margaret Haney, Amie S Ward et al.
Studies have shown that the Delta(9)-tetrahydrocannabinol (Delta(9)-THC) concentration in marijuana cigarettes is an important factor for the maintenance of marijuana self-administration. Yet, the impact of oral Delta(9)-THC treatment on marijuana self-administration is unknown. Because other agonist therapies have been demonstrated to be effective for the treatment of substance use disorders,...
Neuropsychopharmacology
November 2001
Carl L. Hart, W Van Gorp, Margaret Haney et al.
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not been adequately assessed under experimental conditions. In the present study, we used a within-participant double-blind design to evaluate the effects acute marijuana smoking on complex cognitive performance in...