European Addiction Research
June 1, 1999
D Basu, Anita S Malhotra, Anumeha Bhagat et al.
Twenty cases of cannabis psychosis were compared with a control group of 20 patients with 'acute schizophrenic episode' on a number of demographic, clinical, illness-related and outcome variables in a case-control study design using a retrospective chart review. The two groups were comparable on demographic, past and family histories of mental illness, premorbid personality, psychomotor...
Psychopharmacology
March 1999
F M Leweke, Udo Schneider, Martin Thies et al.
Binocular depth inversion represents an illusion of visual perception that is sensitive to various behavioural and psychiatric conditions. It is affected by cannabinoids, reflecting associated changes in perception. The present study investigated the differences in binocular depth inversion of different classes of natural and artificial objects and the effect of synthetic...
Behavioural Brain Research
February 15, 1999
G Presburger, J K Robinson
Cannabinoid receptors have been implicated as having important roles in human cognitive processes, especially memory and attention. While some work has studied the effects of the active ingredient in marijuana, delta-9-tetrahydrocannabinol (THC), on short-term memory, no work has examined the involvement of these receptors in mediating attention. Therefore, the present study compared the...
Psychopharmacology
February 1, 1999
Margaret Haney, Amie S Ward, S D Comer et al.
Symptoms of dependence and withdrawal after the frequent administration of high doses (210 mg/day) of oral delta9-tetrahydrocannabinol (THC) have been reported, yet little is known about dependence on lower oral THC doses, more relevant to levels attained by smoking marijuana. In a 20-day residential study, male (n = 6) and female (n = 6) marijuana smokers worked on five psychomotor tasks...
Gynäkologisch-geburtshilfliche Rundschau
1999
Ursula Von Mandach, Michael M. Rabner, Joseph Wisser et al.
Im dargestellten Fall geht es um eine 27jährige Patientin, die bis zum Zeiptunkt des positiven Schwangerschaftstests, entsprechend 74/7 Schwangerschaftswochen (p.c.), täglich einen Joint (Cannabis) und 20 Zigaretten (Tabak) geraucht hat. Am 20. Tag p.c. erfolgte ein LSD-Minitrip. Das Sichten der Literatur ergab beim Tier in vitro Chromosomenaberrationen mit LSD. Beim Menschen stehen...
Psychopharmacology
December 1998
Torbjörn U C Järbe, R J Lamb, Alexandros Makriyannis et al.
The objective of this study was to examine if (R)-methanandamide, a metabolically stable chiral analog of the endogenous ligand anandamide, is a cannabimimetic with a lower efficacy than delta9-THC. Employing a two-lever choice drug discrimination procedure, rats were trained to discriminate between 1.8, 3.0, or 5.6 mg/kg delta9-tetrahydrocannabinol (delta9-THC) and vehicle. Different training...
Drug and Alcohol Review
December 1, 1998
W Hall
This paper reviews evidence on two hypotheses about the relationship between cannabis use and psychosis. The first hypothesis is that heavy cannabis use may cause a "cannabis psychosis"-a psychosis that would not occur in the absence of cannabis use, the symptoms of which are preceded by heavy cannabis use and remit after abstinence. The second hypothesis is that cannabis use may precipitate...
Behavioural Pharmacology
November 1998
A Liguori, C P Gatto, J H Robinson
Delta-9-tetrahydrocannabinol (THC) is frequently found in the blood of drivers involved in automobile accidents, and marijuana use has been associated with impaired field sobriety test performance. The present study used a within-subject design to compare the effects of marijuana (0, 1.77, or 3.95% THC) on equilibrium and simulated driving. Ten marijuana users (seven men, three women) smoked...
Brain Research
June 29, 1998
R J Mathew, W H Wilson, T G Turkington et al.
Because marijuana continues to be the most commonly used illicit drug, its effects on the brain function are of major interest. We utilized positron emission tomography (PET) and magnetic resonance imaging (MRI) to study the effects of delta-9-tetrahydrocannabinol (THC) infusion on brain blood flow and its behavioral correlates in 46 volunteers. Consistent with previous reports, there was a...
The Journal of Clinical Psychiatry
April 15, 1998
Malcolm B. Bowers
10 citations
Article AbstractSir: Marijuana use has been associated with mental illness for more than a century and a half. This relationship was first noted by J. J. Moreau de Tours in his 1845 classic work, Hashish and Mental Illness. Observations by Indian psychiatrists kept the topic alive during the first half of this century.