American Journal of Psychiatry
April 17, 2026
Shih-Hsuan Ku, Sierra J Stringfield, Mary M Torregrossa et al.
The relationship between the endocannabinoid system and the emergence and treatment of schizophrenia-related symptoms continues to be a topic of significant interest within psychiatry. Cannabis is the most widely used recreational drug worldwide, and individuals with schizophrenia use it at a much higher rate than the general population. The shared genetic risk for schizophrenia and cannabis...
The International Journal of Neuropsychopharmacology
April 1, 2026
Mary M Torregrossa, Tamara Racic, S. Baglot et al.
Abstract Background Most substance users are polysubstance users; however, little is known about how the combined use of different drugs affects the course of substance use disorder or effectiveness of treatment. Notably, co-use of cannabis and nicotine is very common, and we previously demonstrated that nicotine enhances the self-administration of a synthetic cannabinoid receptor agonist and...
Psychopharmacology
April 8, 2025
Megan L Bertholomey, Camryn Forbes, Bryan D McElroy et al.
3 citations
Alcohol use and major depressive disorder are frequently comorbid, with individuals diagnosed with a substance use disorder being nearly three times as likely to have major depression. Poor treatment responses are found for both disorders and are further complicated when they co-occur, underscoring the need for better therapies. One potential candidate is ketamine, which has been shown to have...
Neuropsychopharmacology
April 2017
Erin K Kirschmann, Michael W Pollock, Vidhya Nagarajan et al.
Use of marijuana (Cannabis sativa) often begins in adolescence, and heavy adolescent marijuana use is often associated with impaired cognitive function in adulthood. However, clinical reports of long-lasting cognitive deficits, particularly in subjects who discontinue use in adulthood, are mixed. Moreover, dissociating innate differences in cognitive function from cannabis-induced deficits is...
Teneisha M. Myers, Noah C. Neverette, Aaron S. Devanathan et al.
preprint
Abstract Rationale Cannabis is the most widely used illicit substance in the United States, and its use is increasing with the recent push for legalization and decriminalization, as well as the growing use for medicinal purposes. While cannabis can have positive effects in some individuals, there are potential negative consequences including dependence, psychosis, and cognitive impairments. The...