Comparative Clinical Trajectories Across Cannabis‐Related and Nonsubstance‐Related Psychoses
Antti Mustonen, Solja Niemelä, Alexander Denissoff, A. Tanskanen, E. Mittendorfer-Rutz, M. Lähteenvuo, J. Tiihonen, H. Taipale
Acta Psychiatrica Scandinavica April 8, 2026 DOI: 10.1111/acps.70097 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | People with first-episode psychosis, including those with cannabis use disorder or cannabis-induced psychosis and those without substance use disorder |
| Topics | Cannabis |
| Key findings | The study suggests that first-episode psychosis with cannabis use disorder or cannabis-induced psychosis has a substantial disease burden, but detailed clinical trajectories remain unclear and require further investigation. |
Abstract
Research indicates that first‐episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis‐related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis‐induced psychosis (CIP) in comparison with FEP without substance use disorder (SUD).
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cites 3
- The Association Between Cannabis Use and Schizophrenia: Causative or Curative? A Systematic Review Cureus July 21, 2020
- A neuropsychological approach to differentiating cannabis‐induced and primary psychotic disorders Early Intervention in Psychiatry August 10, 2022
- Cannabis, Psychosis, and Mortality: A Cohort Study of 50,373 Swedish Men. American Journal of Psychiatry August 1, 2016