Physiological research
May 12, 2026
Marcel Bochin, Čestmír Vejmola, Vlastimil Koudelka et al.
Cannabinoids modulate brain network activity, yet the spatial organization and temporal evolution of their electrophysiological effects remain insufficiently characterized in animal models. Here, we investigated how acute oral administration of ?9-tetrahydrocannabinol (THC; 10 mg/kg), cannabidiol (CBD; 10 mg/kg), and their combination influences resting-state EEG dynamics in freely moving rats....
Psychopharmacology
May 11, 2026
Gabrielle Abbott, Lisa-Marie Greenwood, Jessica G. Bartschi et al.
Abstract Introduction The regular consumption of cannabis has been associated with changes in cognition. However it is unclear how cognitive performance changes over time with continued cannabis use and whether cognitive alterations predate the onset of cannabis use. We conducted a narrative review of longitudinal observational naturalistic studies of cognition in people who use cannabis....
Neuropsychopharmacology
May 9, 2026
Ana Maria Raymundi, Nathalie Carla Cardoso, Gabriel Costa Lourenço et al.
In PTSD, microglia are more engaged in fear-related circuits, where they participate in fear memory processing responses. The reconsolidation-impairing effect of Δ⁹-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis, is typically linked to cannabinoid type-1 receptor (CB1) signaling. THC also engages peroxisome proliferator-activated receptor gamma (PPARγ), and both...
Neuropsychopharmacology
May 9, 2026
Claudia Poluga, S. S. Dheda, Nadia Boachie et al.
Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments. The endocannabinoid enzyme fatty acid amide hydrolase (FAAH) may influence cannabis use and withdrawal, but the relationship between FAAH levels and withdrawal symptoms remains unclear. This study aims to investigate changes in FAAH levels during short-term abstinence from cannabis...
SLEEPJ
May 8, 2026
Sandeep Banga, Brooke Judd
Abstract: Introduction: Limited prior studies and case reports have assessed the effects of marijuana use and withdrawal on sleep architecture, including alterations in REM sleep. In particular, these have suggested an increase in REM and reduction in REM latency with abrupt discontinuation of chronic marijuana use. This case report examines a patient with suspected narcolepsy type 1 and...
NeuroSci
May 7, 2026
Andrei Buciuta, Horia George Coman, Bogdan Nemeș et al.
Background: Only a subset of cannabis users develop persistent psychosis, implying that genetic vulnerability modulates risk. HLA-DR/DQ variation is a strong non-dopaminergic risk locus for schizophrenia, but its role in cannabis-related psychosis is unclear. Methods: We studied 296 cannabis users from Romanian psychiatric services, grouped as non-psychosis (0), non-schizophrenia psychosis (1)...
Psychopharmacology
May 7, 2026
Emillie Beyer, Martine Skumlien, Govinda Poudel et al.
Cannabis Use Disorder (CUD) affects ~ 50 million individuals worldwide and is associated with alterations in brain reward pathways. Mindfulness-based interventions (MBIs) show promise in reducing substance use and aberrant brain function in substance use disorders (SUD), but the effects on CUD or brain reward function have not been investigated. To examine whether a 2-week MBI vs. active...
Cannabis
May 6, 2026
Mark J. Crisafulli, Jessica N. Flori, Michael Dunn
Objective: There have been widespread increases in cannabis use as recreational and medical use has become legal across the globe. Changes to the chemical makeup of cannabis may have changed residual effects experienced by individuals who use cannabis, and more individuals may be affected. Method: We conducted a meta-analysis examining the neurocognitive effects of cannabis after abstinence...
International Journal of Science and Research (IJSR)
May 5, 2026
Ashna Saeed
: Cannabis is one of the most widely used psychoactive substances worldwide, and its increasing legalization has intensified interest in its neurological effects. This paper reviews existing research on how cannabis use affects brain function, focusing on cognitive processes, brain structure, and long-term outcomes. The primary psychoactive compound in cannabis, delta-9-tetrahydrocannabinol...
International Journal of Mental Health and Addiction
May 5, 2026
Cerina Dubois, Amrit Baral, Riana Durrett et al.
An emerging approach called California Sober (CS) has gained attention for promoting abstinence of all intoxicating substances except cannabis and potentially, psychedelics. Cannabis legalization and the expansion of cannabis products have introduced new complexities in addiction recovery, challenging traditional abstinence-based frameworks such as Alcoholics Anonymous (AA), which define...