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NeuroSci

ISSN 2673-4087

7 papers in the library · 4 citations · publishing 2022-2026

Papers

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HLA Class II Immunogenetic Profiles Shape Psychosis Outcomes in Cannabis Users: DRB5/DRB1*16 Vulnerability and DRB4/DRB3-Linked Protection, Particularly Against Schizophrenia

NeuroSci May 7, 2026 Andrei Buciuta, Horia George Coman, Bogdan Nemeș et al.

Background: Only a subset of cannabis users develop persistent psychosis, implying that genetic vulnerability modulates risk. HLA-DR/DQ variation is a strong non-dopaminergic risk locus for schizophrenia, but its role in cannabis-related psychosis is unclear. Methods: We studied 296 cannabis users from Romanian psychiatric services, grouped as non-psychosis (0), non-schizophrenia psychosis (1)...

DOI: 10.3390/neurosci7030056 (opens in new tab)

Ketamine's Therapeutic Role in Substance Use Disorders: A Narrative Review.

NeuroSci August 27, 2025 Alexander Thomas, R Andrew Chambers 4 citations

Interest in ketamine as a novel treatment for substance use disorders (SUDs) has been increasing due to its N-methyl-D-aspartate (NMDA) glutamate receptor antagonism and mounting evidence that glutamate neurotransmission is involved in the pathogenesis of both depression and addictions. This narrative review provides an outline of clinical evidence reported in the literature from the 1970s to...

DOI: 10.3390/neurosci6030083 (opens in new tab) Full text (opens in new tab) Ketamine Nmda n-methyl-d-aspartate Case reports Cohort studies +3

Proprioceptive Resonance and Multimodal Semiotics: Readiness to Act, Embodied Cognition, and the Dynamics of Meaning

NeuroSci May 12, 2025 Marco Sanna

This paper proposes a theoretical model of meaning-making grounded in proprioceptive awareness and embodied imagination, arguing that human cognition is inherently multimodal, anticipatory, and sensorimotor. Drawing on Peircean semiotics, Lotman’s model of cultural cognition, and current research in neuroscience, we show that readiness to act—a proprioceptively grounded anticipation of...

DOI: 10.3390/neurosci6020042 (opens in new tab)

Neuroanatomy of the Will.

NeuroSci December 1, 2022 James William Hendry Sonne

Questions regarding the nature and source of consciousness and individual agency to make decisions have enormous practical implications that include human health and wellbeing, social policy, and economics. Ethical issues involving the ability for patients to make conscious, informed choices, such as in cases of dementia or coma, abound, and the health implications of individual choice on...

DOI: 10.3390/neurosci3040044 (opens in new tab) Full text (opens in new tab)