Long-chain polyunsaturated fatty acids (LC-PUFAs) are crucial for brain development, with ω-3 species supporting neuronal membrane architecture, synaptogenesis and cognitive maturation, and ω-6 species linking lipid metabolism to neuronal signalling via the endocannabinoid system (ECS), the network of receptors, lipid mediators, and enzymatic pathways that orchestrate neurodevelopmental...
Retail sales of intoxicants, including derived intoxicating cannabis products (DICPs) such as delta-8 tetrahydrocannabinol (THC) and hallucinogenic mushrooms, have rapidly increased throughout the US, despite their sale being federally illegal. This study assessed DICP and hallucinogenic mushroom availability in US smoke shops with differing DICP and psilocybin laws. In May-October 2025, using...
Frontiers in PsychologyMay 28, 2026Lidia Venero-Hidalgo, Francisca Carvajal, Fernando Rodrı́guez de Fonseca et al.
Introduction: Cannabis use during adolescence and young adulthood has been associated with neurocognitive alterations. However, limited attention has been paid to whether these findings vary according to developmental stage and regional context. This systematic review examined the neurocognitive effects of cannabis use in adolescents and young adults, with particular attention to age-related...
Cannabis continues to be the most widely used illicit drug, usually used recreationally without significant problems occurring. Concerns remain over long term health of users and the possibility of associations with mental illness. Surveys suggest regular use remains common amongst teenage males, taking place concurrently with the period when teenagers are engaged in identity development and...
NeuroscienceMay 25, 2026Caitlyn C Costa, Aoife S Weiss, Caroline M Limbaker et al.
Rates of cannabis use continue to rise, however, the neurocognitive effects are not fully characterized. Deficitsin memory processes, especially in adolescents, have been reportedfollowing exposure toΔ9-tetrahydrocannabinol (THC), the main psychoactive componentin cannabis. Treatments addressing these deficits have been unsuccessful. Here, we test the hypothesis that vaporized THC/cannabis...
Functional recovery in cannabis-induced first-episode psychosis (FEP) remains incompletely understood. Dissociative symptoms, frequently associated with cannabis use, may represent a key but underexplored determinant of functional trajectories. This prospective cohort study followed 72 patients meeting DSM-5 criteria for cannabis-induced psychotic disorder over 24 months. Functional recovery...
New research on the relationship between cannabis and psychosis was released, and a presentation on how low‐dose buprenorphine combined with ketamine reduced suicidality in adults with major depressive disorder was published and presented at the annual meeting of the American Psychiatric Association (APA).
Major Depressive Disorder (MDD) is a highly prevalent and disabling psychiatric disorder, representing a major global health burden across all age groups. Increasing evidence indicates that its pathophysiology involves a complex interplay between chronic stress, dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, immune activation, and neuroinflammation. Persistent HPA axis...
Research SquareMay 18, 2026Samuel M. DiCecco, Emma E Smith, Kira L. Sturgess et al.
preprint
Abstract Rationale: Fast-acting edible cannabis products are marketed as producing quicker effects than standard edibles, but whether faster absorption translates into earlier cognitive impairment due to cannabis intoxication is unclear. Objectives : We compared fast-acting, standard, and placebo edibles in a double-blind, within-subject crossover study of 20 adult individuals who frequently...
Background Cannabis use is associated with increased risk of psychotic disorders, but the underlying biological mechanisms remain unclear. We used genetic data to investigate the molecular pathways contributing to the association between cannabis use disorder (CUD) and psychosis. Methods We conducted a cross-disorder meta-analysis of genome-wide association studies (GWASs) on schizophrenia and...