Biomolecules
September 10, 2024
Valeria Lallai, TuKiet T Lam, Rolando Garcia-Milian et al.
Given the increasing use of cannabis in the US, there is an urgent need to better understand the drug's effects on central signaling mechanisms. Extracellular vesicles (EVs) have been identified as intercellular signaling mediators that contain a variety of cargo, including proteins. Here, we examined whether the main psychoactive component in cannabis, Δ9-tetrahydrocannabinol (THC), alters EV...
L'Encephale
September 1, 2024
Zélie Billion, M. Hein
INTRODUCTION Cannabis is the most consumed illicit substance in Europe. Although its sale and use remain generally prohibited, European public policies have evolved in recent years by legalizing cannabis for medical use and considering its legalization for recreational use. However, in the literature there are arguments in favor of a particular relationship between cannabis consumption and the...
Psychiatry Research
September 1, 2024
Giuseppe D'Andrea, Clairélaine Ouellet-Plamondon, Marie Villeneuve et al.
Cannabis use is associated with increased psychosis incidence alongside worse outcomes. The role of cannabis may be complex, vary across patients and over time. Yet, few have examined the longer-term trajectories of cannabis use, symptoms and functioning and their inter-relationships. We conducted a 5-year longitudinal study to estimate joint-trajectories of clinical severity, social...
Drug and Alcohol Dependence
September 1, 2024
R P Bell, J R Cohen, Sheri L Towe et al.
Cannabis is commonly used in the United States. However, chronic cannabis use has been linked to alterations in white matter (WM) integrity. Studies investigating WM in people who use cannabis (PWC) have produced varying results, which may be due to a variety of factors, including a focus on individual WM tracts. Here, we examined WM connectivity using a module-based approach to help clarify...
Journal of Psychiatric Research
September 1, 2024
Noah R Wolkowicz, Mehmet Sofuoglu, Brian Pittman et al.
Attentional bias (AB) is believed to be an important factor in the development and maintenance of both opioid use disorder (OUD) and chronic pain. Cannabis and its main psychoactive constituent, delta-9-tetrahydrocannabinol (THC), produce analgesic effects via processes that are potentially relevant to AB and is commonly used by persons with OUD. This exploratory study investigated if THC...
Pharmacology, Biochemistry, and Behavior
September 1, 2024
Samantha L Penman, Nicole M Roeder, Jia Wang et al.
9 citations
There has been an increasing use of cannabis during pregnancy in recent years. Studies have indicated that THC exposure in utero may increase the risk of attention deficits and memory impairments in adolescence. The goal of the present study is to investigate the effects of vaporized THC exposure during pregnancy on offspring memory and attention performance in early and late adolescence....
European Psychiatry
August 27, 2024
Daniele Zullino, Louise Penzenstadler, Stéphane Rothen et al.
Introduction While research on drug use motives has primarily focused on widely used substances like alcohol, tobacco, and cannabis, understanding the motivations behind MDMA use is crucial for developing targeted therapeutic, preventive, and harm reduction strategies. Objectives The objective of this study is to present the findings of an online survey that evaluates the motives behind the use...
Addiction
August 13, 2024
Beau Kilmer
3 citations
An increasing number of US states and localities are implementing or considering alternatives to prohibiting the supply and possession of some psychedelics for non-clinical use. Debates about these policy changes will probably differ from what we saw with cannabis. Andrews et al. correctly note that: 'The current push to broaden the production, sale, and use of psychedelics bears many parallels...
Frontiers in Psychology
August 12, 2024
Maitane Oscoz-Irurozqui, Maria Guardiola-Ripoll, Carmen Almodóvar-Payá et al.
Introduction Research data show the impact of the endocannabinoid system on psychosis through its neurotransmission homeostatic functions. However, the effect of the endocannabinoid system genetic variability on the relationship between cannabis use and psychosis has been unexplored, even less in first-episode patients. Here, through a case-only design, we investigated the effect of cannabis...
Cannabis and Cannabinoid Research
August 2024
Laura MacNair, Graham M L Eglit, Irina Mosesova et al.
Introduction: A growing number of females report consuming cannabis products. There is a paucity of data on sex differences in safety and subjective effects after repeated use of varying oral doses of Δ9-tetrahydrocannabinol (THC; the primary psychoactive constituent of cannabis). Materials and Methods: Data were from two randomized, double-blind, placebo-controlled, multiple-dose,...
Current Topics in Medicinal Chemistry
August 1, 2024
Valerio Ricci, Domenico de Berardis, Giovanni Martinotti et al.
Background: Cannabis is the most widely used illicit substance. Numerous scientific evidence confirm the strong association between cannabis and psychosis. Exposure to cannabis can induce the development of psychosis and schizophrenia in vulnerable individuals. However, the neurobiological processes underlying this relationship are unknown. Neurotrophins are a class of proteins that serve as...
Human Brain Mapping
August 1, 2024
Mikki Schantell, Jason A John, Anna T Coutant et al.
Regular cannabis use is associated with cortex-wide changes in spontaneous and oscillatory activity, although the functional significance of such changes remains unclear. We hypothesized that regular cannabis use would suppress spontaneous gamma activity in regions serving cognitive control and scale with task performance. Participants (34 cannabis users, 33 nonusers) underwent an interview...
Journal of Psychopharmacology
August 1, 2024
Camilo A Castelblanco, Seth D Springer, Mikki Schantell et al.
Cannabis is the most widely used psychoactive drug in the United States. While multiple studies have associated acute cannabis consumption with alterations in cognitive function (e.g., visual and spatial attention), far less is known regarding the effects of chronic consumption on the neural dynamics supporting these cognitive functions. We used magnetoencephalography (MEG) and an established...
Schizophrenia Research
July 30, 2024
L. Kennedy, B. Ku, Jean Addington et al.
Background: Neurocognitive deficits have been widely reported in clinical high-risk for psychosis (CHR) populations. Additionally, rates of cannabis use are high among CHR youth and are associated with greater symptom severity. Cannabis use has been sometimes shown to be associated with better neurocognition in more progressed psychosis cohorts, therefore in this study we aimed to determine...
Schizophrenia Research
July 16, 2024
I. Kreis, T. Lagerberg, K. F. Wold et al.
BACKGROUND Data-driven classification of long-term psychotic symptom trajectories and identification of associated risk factors could assist treatment planning and improve long-term outcomes in psychosis. However, few studies have used this approach, and knowledge about underlying mechanisms is limited. Here, we identify long-term psychotic symptom trajectories and investigate the role of...
Journal of Cannabis Research
July 11, 2024
Cianna J Piercey, Eleftherios Hetelekides, Hollis C Karoly
5 citations
Background: Most studies examining the simultaneous use of cannabis with other drugs have focused on cannabis and alcohol, with fewer studies examining simultaneous use of cannabis with other drugs. The United States is currently experiencing an upward trend in psychedelic use and there is an increasing need to characterize cannabis and psychedelic drug interactions to best inform public health...
Psychoactives
July 3, 2024
Rosa María Moret, Sergio Sanz‐gómez, Santiago Gascón et al.
4 citations
Substance use/abuse and suicide are two closely related phenomena, mostly due to neurobiological, psychological, and social impairments. In the present narrative review, the relationship between suicidal behavior (SB) and the use and abuse of common recreational drugs, such as alcohol, cannabis, cocaine, methamphetamine, heroin, nicotine, ketamine, psilocybin, MDMA, and LSD, has been explored....
Journal of Psychoactive Drugs
July 3, 2024
Bruno Romeo, Ewen Kervadec, Baptiste Fauvel et al.
5 citations
Treating cannabis use disorder remains a significant challenge in the field of addiction medicine. Some recent studies point to psychedelic-assisted psychotherapy as a potential treatment option for substance use disorders. The objective of this study was therefore to explore the impact of naturalistic psychedelic experiences on cannabis use and psychological flexibility. An online...
Journal of Psychoactive Drugs
June 29, 2024
Dima Audi, Shorouk Hajeer, Marie-belle Saab et al.
ABSTRACT Cannabis is one of the most commonly utilized recreational drugs. However, increasing evidence from the literature suggests harmful implications on cognition. Thus, the main aim of the current review is to summarize literature findings pertaining to the impact of cannabis on neurocognitive skills, focusing on the imaging biomarkers provided by MRI. Two reviewers navigated the...
Cells
June 29, 2024
Kawsar U Chowdhury, Madison Elizabeth Holden, Miles T Wiley et al.
There has been a significant increase in the consumption of cannabis for both recreational and medicinal purposes in recent years, and its use can have long-term consequences on cognitive functions, including memory. Here, we review the immediate and long-term effects of cannabis and its derivatives on glutamatergic neurotransmission, with a focus on both the presynaptic and postsynaptic...