Effects of Cannabis Use on Neurocognition: A Scoping Review of MRI Studies
Dima Audi, Shorouk Hajeer, Marie-belle Saab, Lea Saab, H. Harati, A. Desoutter, E. Al Ahmar, Elias Estephan
Journal of Psychoactive Drugs June 29, 2024 DOI: 10.1080/02791072.2024.2372377 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key findings | The review of 47 studies indicates that cannabis users show cognitive deficits, with task-based fMRI revealing both decreased and increased neuronal activity in task-related brain regions. The authors argue that MRI is a key tool for understanding these effects and call for further research to validate cannabis's harms and guide public health measures. |
Abstract
ABSTRACT Cannabis is one of the most commonly utilized recreational drugs. However, increasing evidence from the literature suggests harmful implications on cognition. Thus, the main aim of the current review is to summarize literature findings pertaining to the impact of cannabis on neurocognitive skills, focusing on the imaging biomarkers provided by MRI. Two reviewers navigated the literature independently using four main search engines including PubMed and Cochrane. Articles were first evaluated through their title and abstract, followed by full-text assessment. Study characteristics and findings were extracted, and the studies’ quality was appraised. 47 articles were included. The majority of the studies were of a case-control design (66%), and the most studied neurocognitive skill was memory (40.4%). With task-based fMRI being the most commonly utilized MRI technique, findings have shown significantly varying decreased and increased neuronal activity within brain regions associated with the cognitive tasks performed. Results suggest that cannabis users are significantly suffering from cognitive deficits. The major significance of this review is attributed to highlighting the role of MRI. Future research needs to delve more into validating the negative effects of cannabis, to enable stakeholders to take action to limit cannabis usage, to foster public health and wellbeing.
Comparable studies
Other systematic reviews and meta-analyses on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Effects of cannabis use on outcomes of psychotic disorders: systematic review People with psychotic disorders, as examined in 13 longitudinal studies | 2008 | Systematic review | |
| The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample Patients with established schizophrenia (meta-analysis: 572) and patients with... | 2010 | Meta-analysis and cross-sectional observational study | n = 700 |
| Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review | 2020 | Systematic review | |
| Neuroimaging in cannabis use: a systematic review of the literature Cannabis users and controls in neuroimaging studies | 2009 | Systematic review | |
| Human Laboratory Studies on Cannabinoids and Psychosis. Healthy human subjects and individuals with schizophrenia | 2016 | Systematic review |
Citations in the library
Cites 22
- The neuropsychopharmacology of cannabis: A review of human imaging studies Pharmacology & Therapeutics October 20, 2018
- Cannabis Dampens the Effects of Music in Brain Regions Sensitive to Reward and Emotion The International Journal of Neuropsychopharmacology August 30, 2017
- Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users Addiction Biology December 22, 2019
- The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers Journal of Psychopharmacology August 5, 2020
- Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity Journal of Psychiatry and Neuroscience February 26, 2020
and 17 more in the library