Psychopharmacology
October 1, 2024
Ardavan Mohammad Aghaei, Lia Urban Spillane, Brian Pittman et al.
9 citations
After a single 10 mg oral dose of THC, women reported a heightened subjective feeling of being 'high' compared to men, while psychotomimetic and physiological effects were similar across sexes. No sex differences appeared in verbal learning and memory. The findings suggest that women may experience a more pronounced subjective psychoactive response to THC, pointing to individual vulnerabilities that could inform tailored interventions for cannabis use disorder.
Cellular and molecular life sciences : CMLS
January 21, 2025
Alejandra Pulido-Saavedra, Henrique Nunes Pereira Oliva, Tiago Paiva Prudente et al.
5 citations
The opioid crisis has driven a search for new treatments for opioid use disorder (OUD). A systematic review of 40 preclinical animal studies found that the psychedelic compounds 18-methoxycoronaridine (18-MC), ibogaine, noribogaine, and ketamine generally reduced opioid self-administration, eased withdrawal symptoms, and altered conditioned place preference. However, seven studies showed no improvement over controls. Most research has focused on iboga derivatives, which appear effective but carry higher cardiovascular risk than other psychedelics. The review calls for more translational and clinical studies that test a broader range of psychedelic agents and explore mechanisms, safety, dosing, and treatment frequency.
Psychiatry Research
June 1, 2025
Jeremy Weleff, Alejandra Pulido-Saavedra, Ardavan Mohammad Aghaei et al.
4 citations
A systematic review of clinical studies on psychedelics for opioid use disorder found few completed trials using serotonergic psychedelics; most investigated ibogaine or ketamine. The evidence is limited by weak study designs focused on opioid withdrawal, few double-blind or placebo-controlled trials, and considerable methodological heterogeneity that makes comparisons across compounds difficult. Most studies had a high risk of bias, mainly due to lack of randomization, blinding, and blinded outcome assessment. The review outlines these limitations and steps to improve the quality of future research in this area.
Frontiers in Psychiatry
January 1, 2025
Scott Matthews, Antonino Greco, Clara Rastelli et al.
1 citation
Virtual reality simulations of psychedelic phenomenology can replicate neurophysiological and behavioral markers of classic serotonergic psychedelics in healthy subjects, suggesting they may serve as an adjunct or replacement for aspects of psychedelic-assisted therapy for alcohol use disorder. The authors propose four clinical applications: preparing patients for psychedelics, extending their efficacy, facilitating integration after dosing, and standardizing the therapeutic set and setting. Virtual reality may also function as a placebo in clinical research and as a tool to study subjective psychedelic experiences. Integrating virtual reality into psychedelic therapy and research could enable new treatment possibilities and implementation pathways.
Frontiers in Psychiatry
October 19, 2023
Brian S. Barnett, Anahita Bassir Nia, Nathan Sackett et al.
1 citation
Psychedelics may offer new treatments for substance use disorders (SUDs), which cause high rates of illness and death. Current treatments often fail: in one trial, 57% of patients on buprenorphine and 65% on naltrexone relapsed by 24 weeks, and 40% leave 12-step groups within a year. This special issue presents seven articles exploring psychedelics' potential for SUDs, including psilocybin for methamphetamine use disorder and ketamine's effects on brain plasticity. One review found mixed evidence for ketamine's impact on synaptic markers in the hippocampus and prefrontal cortex. A perspective piece argues for equitable access to psychedelic therapies, including training diverse clinicians and serving higher-risk patients.
Current Addiction Reports
January 1, 2025
Anahita Bassir Nia, Yalda Farahmand, Garret Griffith et al.
A review of trials on psychedelics for opioid use disorder (OUD) found no studies directly comparing different types of psychotherapy or testing psychedelics with versus without concurrent psychotherapy. Most research on alleviating opioid withdrawal symptoms did not include psychotherapy. The few studies on ketamine and LSD for opioid use and abstinence used a psychedelic-assisted therapy model. There is insufficient high-quality evidence to determine whether concurrent psychotherapy is necessary in psychedelic trials for OUD. Future trials should explore the interplay between psychedelic treatment and psychotherapy.