ABSTRACT: Motivated by multiple factors collectively related to what is often termed the Psychedelic Renaissance, people increasingly consume psychedelics for recreational, medicinal, psychotherapeutic, and even spiritual or religious reasons. In the broader psychedelic ecosystem, ayahuasca (a psychoactive "tea" made from plants indigenous to the Amazon jungle) is becoming one of the more...
Ayahuasca is a psychoactive drink originally consumed by indigenous people of the Amazon. The lack of regulation of this drink leads to uncontrolled consumption, and it is often consumed in religious contexts. The aim of this work is to compare three miniaturised extraction techniques for extracting the main ayahuasca compounds from beverages. Three sample pretreatment techniques were evaluated...
Neste trabalho, situamos o município de Marabá, no sudeste do Pará, sua constituição histórica, social e cultural. Refletindo a relação das pessoas com os rios afluentes da cidade - Tocantins, Itacaiunas e Araguaia -, os períodos de inverno/verão amazônico e sua importância para a manutenção de práticas culturais e xamânicas. Foi realizada uma pesquisa no Instituto Xamânico Céu da Ayahuasca,...
Background: How the human psyche interacts with the theme of death is fundamental to individual and societal life, profoundly influencing cognition, affect, and behavior. Death-related psychological phenomena, such as death anxiety and acceptance, have been shown in clinical studies to be influenced by psychedelic (LSD and psilocybin) interventions. However, the literature lacks a comprehensive...
Estudos de ReligiãoJuly 23, 2024João Paulo Salles Pinto, Leonel Severo Rocha
Que o direito e a ordem jurídica tem a ver, sobretudo, com uma maneira de violência culpabilizante e essencial da vida, trata-se, sem embargo, da premissa principal das análises dos textos jurídicos de Walter Benjamin. Tais reflexões e posicionamentos permitem, não obstante, um revisitar dos modernos modos de se compreender a relação entre ação, prática e direito, a partir e, em especial, de...
Ayahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,N-dimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca...
CureusJuly 1, 2024Elliot Hernandez, David Dominguez, Raul Medina-Rioja et al.1 citation
We present the case of a 60-year-old male patient with Guillain-Barré syndrome (GBS) who experienced treatment-related fluctuations (TRF) with a history of ayahuasca consumption. The patient presented to the neurological emergency department without a history of infection (upper respiratory tract or diarrhea) or vaccination in the past four weeks, but 14 days prior, the patient had consumed...
Psychedelics, substances known to alter perception, mood, and consciousness, have been used across various cultures for centuries, often in religious ceremonies to facilitate spiritual experiences. Lysergic acid diethylamide (LSD) was used clinically from the 1950s until its ban in 1967. Recently, there has been a resurgence of interest in psychedelics for treating mental health disorders such...
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classical serotonergic psychedelic, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on resting-state FC in nonhuman primates. We highlight overlapping and...
Abstract Background Hallucinogens attract research as alternatives to the commonly used medications to treat major depressive and anxiety disorders. Aims Assess hallucinogens’ efficacy for managing depressive and anxiety symptoms and evaluate their safety profiles. Method In five databases, we searched for randomized controlled trials of hallucinogens targeting depressive and anxiety symptoms....
Ayahuasca is a psychedelic plant brew originating from the Amazon Rainforest. It is formed from two basic components, the Banisteriopsis caapi vine, and a plant containing the potent psychedelic dimethyltryptamine (DMT), usually Psychotria viridis. There has been a dramatic increase in interest surrounding ayahuasca since the turn of the millennium. Increasing numbers of tourists are travelling...
Surveying contemporary networks and practices in Peru, Australia, and China, anthropologist Alex K. Gearin explores the visionary marvels, wonders, and diversity of ayahuasca drinking today. Ceremonies of drinking the psychoactive brew ayahuasca have flourished across the planet in recent decades. Emerging from Indigenous roots in the Amazon rainforest, the brew is now envisaged by many as the...
Ayahuasca, un té utilizado inicialmente por pueblos amerindios, con fines medicinales, religiosos y sacramentales, y luego se difundió en muchas partes del mundo en contextos urbanos, que, además de su uso religioso y espiritual, también el uso recreativo. El té de ayahuasca contiene un perfil químico bien característico de compuestos alcaloides psicoactivos que son N, N-dimetiltriptamina (DMT)...
The psychedelic beverage ayahuasca is originally obtained by Banisteriopsis caapi (B. caapi) (BC) and Psychotria viridis (P. viridis) (PV). However, sometimes these plant species are replaced by others that mimic the original effects, such as Mimosa hostilis (M. hostilis) (MH) and Peganum harmala (P. harmala) (PH). Its worldwide consumption and the number of studies on its potential therapeutic...
Ayahuasca (AYA) is a botanical psychedelic with promising results in observational and small clinical trials for depression, trauma and drug use disorders. Its psychoactive effects primarily stem from N,N-dimethyltryptamine (DMT). However, there is a lack of research on how and where AYA acts in the brain. This study addressed these questions by examining the extinction of aversive memories in...
Revista NeurociênciasMay 28, 2024Mariah Caroline Charafeddine Dias, Rafael Mariano de Bitenocurt
Introdução. A depressão afeta mais de 300 milhões de pessoas globalmente, é considerada uma das principais preocupações de saúde pública, sendo referida como o "mal do século". Caracterizada por diversos sintomas, desde tristeza profunda até pensamentos suicidas, o tratamento convencional envolve o uso de antidepressivos, frequentemente acompanhados de psicoterapia, mas a eficácia é variável e...
The consumption of ayahuasca for cultic purposes: public health order and religious freedom ABSTRACT: The article is inspired by the arguments contained in judgement no. 9897 of 2023 of the Council of State, which rejected the appeal against the inclusion of ayahuasca in the table of psychotropic substances. This narcotic is used in small quantities in the celebrations of the Churches of Daime,...
Abstract Background Ayahuasca, a psychoactive Amazonian preparation, is increasingly studied for substance-use disorders. Objectives Investigate whether oral lyophilised-ayahuasca attenuates ethanol-induced conditioned place preference (CPP) in mice and alters ΔFosB expression in nucleus accumbens (NAc). Methods Male Swiss mice received water or ayahuasca (130-1950 mg/kg, p.o.) 30 min before...
Rumination is a well-established risk factor for the onset and maintenance of depression and anxiety and has been identified as a transdiagnostic factor due to its association with multiple forms of psychopathology. A renaissance of psychedelic research shows promise in treating psychopathology with potential for acting on ruminative processes. Despite the growing interest and developments in...
Plain Language Summary A suicidal patient with Short‐lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing (SUNCT) whose excruciating condition did not respond to various treatments discovered that ayahuasca, a psychoactive concoction used by indigenous populations of South America, caused his attacks to cease entirely. Inhaled N , N ‐dimethyltryptamine (DMT),...