2010
C. Ilic, D. Marinkovic, V. Brkic et al.
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best-known representative drug from the compound class of arylcyclohexylamines. On a pharmacological activities basis, it belongs to the family of drugs known as dissociative anesthetics. In recent years, great attention has been paid to the investigation of substances that have been abused, including PCP. PCP is a synthetic drug with...
Addiction Biology
2010
Nora Von Ameln, Andreas Von Ameln‐mayerhofer
14 citations
ABSTRACTDespite the great popularity of 3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy) as a drug of abuse, not much is known about the detailed mechanisms of the acute and subchronic effects of the drug. There is especially a lack of information about the distinct behavioural effects of its optical isomers (enantiomers) R‐ and S‐MDMA compared with the racemic RS‐MDMA. For this purpose,...
The Journal of Toxicological Sciences
2010
Asuka Kaizaki, Sachiko Tanaka, Kenji Tsujikawa et al.
14 citations
3,4-Methylenedioxymethamphetamine (MDMA) is widely abused as a psychoactive recreational drug. It is well known that MDMA induces neurotoxic damage of serotonergic nerve endings. Although drug abuse is increasing among youths, it is unclear whether recreational drugs affect the development of nerve growth. Thus, the present study examined the effect of recreational drugs, such as MDMA,...
Neophilologica
December 31, 2009
Anna Kuncy
This article aims to analyze the concept of meditation (meditazione) in the Italian language, with special emphasis on the role of body, movement and space in the conceptualization process. The research presented is based on the following theories: Idealized Cognitive Models by G. Lakof f (1987) and thematic proto-roles by D.R. Dowty (1991). Three basic cognitive models for meditation have been...
Cognitive Processing
December 16, 2009
B Rael Cahn, Arnaud Delorme, John Polich
Long-term Vipassana meditators sat in meditation vs. a control rest (mind-wandering) state for 21 min in a counterbalanced design with spontaneous EEG recorded. Meditation state dynamics were measured with spectral decomposition of the last 6 min of the eyes-closed silent meditation compared to control state. Meditation was associated with a decrease in frontal delta (1-4 Hz) power, especially...
Toxicology and Applied Pharmacology
December 15, 2009
Julien Fonsart, Marie-Claude Menet, Marcel Debray et al.
The use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has increased in recent years; it can lead to life-threatening hyperthermia and serotonin syndrome. Human and rodent males appear to be more sensitive to acute toxicity than are females. MDMA is metabolized to five main metabolites by the enzymes CYP1A2, CYP2D and COMT. Little is presently known about sex-dependent differences in the...
Journal of Neuroscience Methods
December 15, 2009
Christian Spang Pedersen, Pascal Goetghebeur, Rebecca Dias
The identification of animal disease-like models for cognitive symptoms in schizophrenia is of central importance to the successful development of pharmacological therapies for psychosis resulting in a functional outcome in patients. Executive function is one of the most severely affected cognitive domains in schizophrenia that remains inadequately treated by existing therapies. The rat...
Behavioural Brain Research
December 14, 2009
Laura A León, Jesus Landeira-Fernandez, Fernando P. Cárdenas
In despite the similarity of mechanisms of action between both selective serotonin reuptake inhibitors (SSRI) and MDMA (main compound of "Ecstasy") there are relatively few reports on the effects of the later on animal models of depression. There are many animal models designed to create or to assess depression. Mild chronic stress (MCS) is a procedure designed to create depression. MCS...
Brain Research
December 11, 2009
Kristal D. Atkins, Tilithia Burks, Alan C. Swann et al.
Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because it produces pleasurable enhancement of such sensation. There have been no electrophysiological studies that report the consequences of MDMA on sensory input. The present study was initiated to study the effects of acute and chronic MDMA on...
December 6, 2009
I. Dowbiggin
Reviewed by: Psychedelic Psychiatry: lsd from Clinic to Campus Ian Dowbiggin Psychedelic Psychiatry: LSD from Clinic to Campus. Erika Dyck. Baltimore: Johns Hopkins University Press, 2008. Pp. 216, $35.00 cloth I’ve lived long enough to remember the 1960s when movies such as Reefer Madness, a film about the health dangers of marijuana, were considered square, moralistic, and unscientific. Then...