European Archives of Psychiatry and Clinical Neuroscience
August 2009
Patrik Roser, Jürgen Gallinat, Gordon Weinberg et al.
Abnormalities in psychomotor performance are a consistent finding in schizophrenic patients as well as in chronic cannabis users. The high levels of central cannabinoid (CB(1)) receptors in the basal ganglia, the cerebral cortex and the cerebellum indicate their implication in the regulation of motor activity. Based on the close relationship between cannabis use, the endogenous cannabinoid...
European Journal of Pharmacology
August 1, 2009
Robert E Vann, Jonathan A Warner, Kristen Bushell et al.
Primarily, rats have served as subjects in Delta(9)-tetrahydrocannabinol's (THC) discrimination studies although other species such as monkeys and pigeons have been used. While the introduction of the knockout and transgenic mice has vastly stimulated the study of the discriminative stimulus effects of drugs there is only a single published report of mice trained to discriminate THC. Thus, this...
The International Journal of Neuropsychopharmacology
August 2009
Guillermo Moreno-Sanz, Esther O'Shea, Laura Orío et al.
Recreational use of (±)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is often associated with other drugs, among which ethanol (EtOH) is one of the most common. However, little is known about how neurochemical sensitization produced by MDMA can modulate EtOH abuse. In this study we used EtOH operant self-administration tasks to investigate the effect of several low doses (0.33, 1.0 and 3.0...
Annals of the New York Academy of Sciences
August 2009
Paul J Rosch
The concept of a "life energy" can be found in many cultures in the present time, as well as in past eras reaching back to the ancients. Variously called qi (chi), ki, the "four humors,"prana, "archaeus,""cosmic aether,""universal fluid,""animal magnetism," and "odic force," among other names, this purported biofield is beginning to yield its properties and interactions to the scientific...
Journal of Cognitive Neuroscience
August 1, 2009
Oliver J Hulme, Karl Friston, Semir Zeki
Most experiments on the "neural correlates of consciousness" employ stimulus reportability as an operational definition of what is consciously perceived. The interpretation of such experiments therefore depends critically on understanding the neural basis of stimulus reportability. Using a high volume of fMRI data, we investigated the neural correlates of stimulus reportability using a partial...
Annals of the New York Academy of Sciences
August 1, 2009
Joseph J. Loizzo
This overview surveys the new optimism about the aging mind/brain, focusing on the potential for self-regulation practices to advance research in stress-protection and optimal health. It reviews recent findings and offers a research framework. The review links the age-related biology of stress and regeneration to the variability of mind/brain function found under a range of conditions from...
Neuropsychopharmacology
July 1, 2009
Adam L. Halberstadt, Iris Van der Heijden, Michael A Ruderman et al.
Although it is well established that hallucinogens act as 5-HT_2A and 5-HT_2C receptor agonists, little is known about the relative contributions of 5-HT_2A and 5-HT_2C receptors to the acute behavioral effects of these drugs. The behavioral pattern monitor was used to characterize the effects of the hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on locomotor and investigatory...
Indian Journal of Psychological Medicine
July 1, 2009
Chaturaka Rodrigo, Senaka Rajapakse
Cannabis is the most widely used illegitimate substance in the world, and the number of users has increased by 10% over the last decade worldwide. Therefore, it is important to review the evidence on psychoactive properties of cannabis and its possible association with schizophrenia spectrum disorders (SSD). We searched MEDLINE with the key words cannabis and schizophrenia. The search was...
PLoS One
June 30, 2009
Dardo G. Tomasi, Nora D. Volkow, Ruiliang Wang et al.
Background Dopamine and dopamine transporters (DAT, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood. Here we hypothesized that dopamine modulates attention by facilitation of brain deactivation in the default mode network (DMN). Thus, higher striatal DAT levels, which would result in an enhanced...
June 24, 2009
Margot Hasha
This multi-component study incorporated the following: (1) an integrated study measuring the impact of a Mindfulness-Based Stress Reduction intervention (MBSR) on potential stressors, appraised stress levels and adaptation to stress of MSW students enrolled in the Louisiana State University School of Social Work through a pretest posttest group design using time-series data to evaluate...