Self-regulation is instantiated by theta oscillations (4 to 8 Hz) in neurons of frontal midline brain regions. Frontal midline theta (FMΘ) is inversely associated with default mode network (DMN) activation, which subserves self-referential processing. Addiction involves impaired self-regulation and DMN dysfunction. Mindfulness is an efficacious self-regulatory practice for treating addiction,...
HGG advancesOctober 13, 2022Alexander Kolevzon, Tess Levy, Sarah Barkley et al.
Activity-dependent neuroprotective protein (ADNP) syndrome is a rare genetic condition associated with intellectual disability and autism spectrum disorder. Preclinical evidence suggests that low-dose ketamine may induce expression of ADNP and that neuroprotective effects of ketamine may be mediated by ADNP. The goal of the proposed research was to evaluate the safety, tolerability, and...
RATIONALE: Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another constituent of cannabis, has anxiolytic properties suggesting that cannabis products containing CBD in addition to THC may produce less anxiety than THC-only products. Findings to date around this issue have been inconclusive and could...
Among 14 subtypes of serotonin receptors (5-HTRs), 5-HT2AR plays important roles in drug addiction and various psychiatric disorders. Agonists for 5-HT2AR have been classified into three structural groups: phenethylamines, tryptamines, and ergolines. In this study, the structure-activity relationship (SAR) of phenethylamine and tryptamine derivatives for binding 5-HT2AR was determined. In...
The preservation of naturally mummified bodies in the Nazca drainage and Yauca Valley provided an opportunity to analyse for the first time which of the psychoactive plants were used on the southern Peruvian coast. Toxicological analysis allows us to better understand the ancient medicine, trade network and religiosity of the region of interest. Hair samples of 22 individuals (including four...
Labyrinths have held the fascination of people since ancient times. Although walking a labyrinth can simply be an interesting recreation, it has increasingly been seen as an intentional tool for personal or spiritual growth. Religious and spiritual experience is generally understood to be a product of the kinds of evidence given within the experience as well as the person’s cognitive and...
E-AcadêmicaOctober 10, 2022Roberto Carlos Moreira Kuligowski, Eduarda Maria Schroeder, João Vitor Pelizzari et al.
Introduction: Studies about alternative medicine have multiplied in several countries such as the United States, Norway and England in recent years. Among them, I highlight psychedelic medicine that through randomized clinical trials, has already shown that psilocybin - substance present in the Psilocybe cubensis mushroom, popularly known as "magic mushrooms" - was able to induce remission of...
Digital platforms could facilitate meditation practice by discriminating the participants’ mental state in real time based on neural activities. However, the search for neural correlates of meditative states yields contradictory results in the literature. To identify the neural signature of meditation, we propose a Random Forest classifier to discriminate between a Focused Attention Meditation...
Depression is a severe mental health problem that affects people regardless of social status or education, is associated with changes in mood and behavior, and can result in a suicide attempt. Therapy of depressive disorders is based mainly on drugs discovered in the 1960s and early 1970s. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)...
BACKGROUND Cannabis is one of the most commonly used substances in the world. However, its effects on human cognition are not yet fully understood. Although the cerebellum has the highest density of cannabinoid receptor type 1 (CB1R) in the human brain, literature on how cannabis use affects cerebellar-dependent learning is sparse. This study examined the effect of chronic cannabis use on...