NMDA-receptor hypofunction is increasingly considered to be an important pathomechanism in schizophrenia. However, to date, it has not been possible to identify patients with relevant NMDA-receptor hypofunction who would respond to glutamatergic treatments. Preclinical models, such as the ketamine model, could help identify biomarkers related to NMDA-receptor function that respond to...
The main aim of this article is to shed light on the intricate relationship between Buddhism and science by focusing on what is becoming an increasingly popular area of contact between the two domains, namely the study of consciousness in the field of cognitive (neuro)science. First, three fundamental ways of approaching the relationship between Buddhism and science are outlined: (a) rejection...
bioRxivJanuary 18, 2023Cristina Delgado-Sallent, Thomas Gener, Pau Nebot et al.
preprint
NMDAR hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP) produces cognitive dysfunction for weeks. We investigated the neural correlates of memory and perceptual impairments in mice treated with sPCP and the rescuing abilities of the...
Major depressive disorder (MDD), also known as clinical depression, is a serious mental disorder and ranks first among psychiatric disorders that dominate the global disease burden. Recently, it was found that psilocybin, active compound derived from psychotropic mushrooms, can relieve depression symptoms rapidly and sustained benefits for several months. Beside MDD, psilocybin can alleviate...
Background: Metacognition refers to appraising one's thoughts and behaviours. Deficits in metacognition are associated with psychosis-spectrum experiences, such as hallucinations and delusions, in both clinical and non-clinical populations. Assessments of metacognitive function and abilities in clinical populations often vary in administration duration, and subjectivity of scores. This study...
arXiv Preprint ArchiveJanuary 12, 2023Charles Johnstone, Prashant S. Alegaonkar
preprint
The way we view the reality of nature, including ourselves, depend on consciousness.It also defines the identity of the person, since we know people in terms of their experiences. In general, consciousness defines human existence in this universe. Furthermore, consciousness is associated with the most debated problems in physics such as the notion of observation, observer,in the measurement...
Harmful usage of tobacco is a global public health problem associated with adverse health effects and addiction. Yet, in the Peruvian Amazon, the native region of Nicotiana rustica L., this plant is used in remarkably different manners: it is considered a potent medicinal plant, applied in liquid form for oral ingestion to treat mental health problems, a common and ancient healing practice in...
Prenatal exposure to maternal immune activation (MIA) and chronic adolescent cannabis use are both risk factors for neuropsychiatric disorders. However, exposure to a single risk factor may not result in major mental illness, indicating that multiple exposures may be required for illness onset. Here, we examine whether combined exposure to prenatal MIA and adolescent...
When trying to give a universal definition to the term “neurophilosophy,” difficulties arise, since each researcher who identifies himself as a member of this field sets his own definition. The common thing for the work of “neurophilosophers” can be described as an interdisciplinary approach, which takes into account the achievements in the field of consciousness research of both philosophical...
Naturally occurring psychedelics have been used for a long time as remedies or in religious ceremonies and recreational activities. Recent studies have proven the therapeutic potential of some psychedelic compounds to safely treat a wide range of diseases such as anxiety, depression, migraine, and addiction. It is hypothesized that psychedelic compounds like tryptamines can exert their effects...