JPI
October 6, 2023
Daniel Parulian Sipahutar, Ismail Petrus, Eryansyah Eryansyah
1 citation
During the pandemic of covid-19, many students have faced social anxiety and stress through the transition from online learning to offline learning. The writer wants to conduct this research due to the finding out of the pandemic and lockdown have brought negative effects for students such as mental health, distress, anxiety, and behavior issues. These conditions are affected students' academic...
Sexual Health & Compulsivity
October 2, 2023
Samridhi Pareek, Gagan Jain, Rajnish Kumar Gupta
4 citations
The Internet makes accessibility to pornography just a click away. However, although most individuals watch porn for fun, a small percentage of porn users develop symptoms similar to addiction. This, in turn, generates interpersonal, occupational, or personal problems for the individual. The present study aims to study the efficacy of mindfulness meditation as a therapeutic tool in reducing...
Argument Biannual Philosophical Journal
October 2, 2023
Tomasz Walczyk
What is extended knowledge and what criteria should it meet? How does the category of cognitive enhancement influence its conceptualisation? Undoubtedly, the history of humanity involves a desire to exceed limits and overcome biological boundaries. As evidenced by research on the extended mind, human cognitive processes are largely dependent on the use of technological supports. The...
bioRxiv
October 2, 2023
Roxane Verdikt, Abigail A Armstrong, Jenny Cheng et al.
preprint
Cannabis, the most consumed illicit psychoactive drug in the world, is increasingly used by pregnant women. However, while cannabinoid receptors are expressed in the early embryo, the impact of phytocannabinoids exposure on early embryonic processes is lacking. Here, we leverage a stepwise in vitro differentiation system that captures early embryonic developmental cascade to investigate the...
JAMA Network Open
October 2, 2023
William G Mantyh, Adam D Block, Madelyn R Castro et al.
Visual hallucinations are a core feature of dementia with Lewy bodies and primary psychiatric disease, yet identification of a hallucination vs normal spiritual experience depends on cultural context. Almost no information exists in the medical literature regarding normal spiritual experiences in American Indian participants in the context of a neurocognitive evaluation. To assess the...
Frontiers in Pharmacology
October 2, 2023
Victor P Acero, Emily S Cribas, Kevin D Browne et al.
20 citations
There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression. Despite promising efficacy observed in some clinical trials, the full range of biological effects and mechanism(s) of action of these compounds...
British Journal of Anaesthesia
October 1, 2023
Andrew J F Turner, Jordan J Wehrman, Robert D. Sanders
The subjective experiences of sedation or anaesthesia are underexplored. A recent study by Valli and colleagues (Br J Anaesth 2023; 131: 348-59) found similar frequency and content of recalled experiences after both non-rapid eye movement sleep and target-controlled infusions of propofol or dexmedetomidine titrated to verbal unresponsiveness. The authors find that the phenomenological...
Molecular Psychiatry
October 2023
Briana J. Hempel, Madeline Crissman, Sruti Pari et al.
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that regulate gene expression. Δ9-tetrahydrocannabinol (Δ9-THC) is a PPARγ agonist and some endocannabinoids are natural activators of PPARα and PPARγ. However, little is known regarding their cellular distributions in the brain and functional roles in cannabinoid action. Here, we first used RNAscope in situ...
British Journal of Anaesthesia
October 2023
Jordan J Wehrman, Cameron P Casey, Sean Tanabe et al.
Sensory disconnection is a key feature of sleep and anaesthesia. We have proposed that predictive coding offers a framework for understanding the mechanisms of disconnection. Low doses of ketamine that do not induce disconnection should thus diminish predictive coding, but not abolish it. Ketamine was administered to 14 participants up to a blood concentration of 0.3 μg ml-1 Participants were...
Pharmacology, Biochemistry, and Behavior
October 2023
Antony D Abraham, Jenny L Wiley, Julie A. Marusich
The co-use of nicotine and cannabis has been steadily rising in the United States. Rodent studies suggest that delta-9-tetrahydrocannabinol (THC) could increase addictive qualities of nicotine, but whether repeated THC exposure alters self-administration of nicotine has not been tested. We hypothesized that THC would increase the reinforcing effects of nicotine and alter nicotine intake. Adult...