In search for the neural correlates of consciousness (NCCs), it is important to isolate the true NCCs from their prerequisites, consequences, and co-occurring processes. To date, little is known about how attention affects the event-related potential (ERP) correlates of auditory awareness and there is contradictory evidence on whether one of them, the late positivity (LP), is affected by...
Complex neuronal interactions underlie cortical information processing that can be compromised in altered states of consciousness. Here intracortical microstimulation was applied to investigate anesthetic state-dependent effective connectivity of neurons in rat visual cortex in vivo. Extracellular activity was recorded at 32 sites in layers 5/6 while stimulating with charge-balanced discrete...
Psychedelic substances, which were once categorized as Schedule 1 drugs, are gaining public attention for their potential to treat individuals with mental conditions. Every Schedule 1 drug was once considered to have no medicinal value, with the potential for high abuse, but recent research has suggested otherwise. LySergic acid Diethylamide (LSD) and MethyleneDioxy-MethAmphetamine (MDMA) are...
Seeing an embodied humanoid avatar move its arms can induce in the observer the illusion that its own (static) arms are moving accordingly, the kinematic signals emanating from this avatar thus being considered like those from the biological body. Here, we investigated the causal relationship between these kinaesthetic illusions and the illusion of body ownership, manipulated through visuomotor...
Abnormally widened spatial and temporal binding windows (SBW/TBWs; length of space/time whereby stimuli are considered part of the same percept) are observed in schizophrenia. TBW alterations have been associated with altered sense of agency (hereafter referred to as agency), and an associative relationship between embodiment (body ownership) and agency has been proposed. SBWs/TBWs are...
OBJECTIVES Understanding variations in knowledge and attitudes of psychiatrists to psilocybin therapy is important for the collective discourse about the potential impact on clinical practice and public health in Ireland. METHODS A 28-item questionnaire was designed based on previous studies and distributed to psychiatrists in Ireland via online mailing lists and at in-person academic events....
The vast majority of treatments for psychiatric and substance use disorders take weeks to work. Notable exceptions to this rule exist, with some treatments such as intravenous ketamine resolving symptoms in minutes to hours. Current research is focused on identifying novel approaches to rapid-acting psychotherapeutics. Promising results from studies of novel classes of drugs and innovative...
L’historiographie en général et celle produite en France en particulier présente traditionnellement les stupéfiants comme des substances indistinctement dangereuses. Ce cadrage systématique sur les phénomènes d’addictions, de déviance et de risques pour l’usager·ère ou la société, repérable par exemple dans la majorité des thèses d’histoire soutenues sur la question des psychotropes, occulte...
The human brain is a unique and complex system where neurotransmitters are not merely biological components but may serve as "divine tools" enabling higher states of consciousness. Endogenous DMT (dimethyltryptamine) emerges as a key substance capable of inducing altered states of awareness linked to profound spiritual and mystical experiences. Research suggests that DMT, produced naturally in...
The term "dissociation" encompasses a wide array of symptoms and phenomena, all sharing the common characteristic of involving altered states of consciousness where an individual temporarily loses the sense of continuity of their own identity. In the context of addiction pathology, however, the dissociative paradigm remains a topic of ongoing debate. It fluctuates between the description of...