Journal of Applied Toxicology
April 8, 2026
Yin Tang, Yanjiao Wang, Liang Meng et al.
5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) has been preliminarily reported to exhibit short-term hallucinogenic effects on humans. However, the connection between its toxic mechanism and behavioral changes remains unexplored. Therefore, this study used zebrafish as the research subject to investigate the metabolic characteristics of 5-MeO-DiPT and its perturbation effects on the metabolic...
Toxics
January 24, 2025
Yin Tang, Kang Yang, Jintao Xu et al.
5 citations
This study investigates the toxic effects of ketamine on juvenile zebrafish, driven by increasing concerns over ketamine's prevalence and its potential neurotoxic effects that may disrupt behavior and metabolism. Employing a high-throughput behavior tracking system, the research analyzed the locomotor activity of 6-day post-fertilization (6 dpf) zebrafish exposed to various concentrations of...
Zhipu Xuebao
September 19, 2024
Yu-Bin Chen, Jiao-Yuan Yu, Liang Meng et al.
This study aimed to assess the neurotoxic effects of the novel psychoactive substance 4-hydroxy-N-methyl-N-isopropyltryptamine (4-HO-MiPT) on brain. By employing zebrafish as a model organism, the study applied a multifaceted approach, including the recording and analysis of spontaneous behavioral activities, identification of brain metabolic products via ultra-high performance liquid...
Ecotoxicology and Environmental Safety
August 30, 2024
Sen Zhao, Meng Liu, Jinyuan Chen et al.
1 citation
Novel Psychoactive Substances (NPS) derived from tryptamines has been detected in aquatic environments, leading to environmental toxicology concerns. However, the specific toxicological mechanism, underlying these NPS, remains unclear. In our previous work, we used 5-Methoxy-N-isopropyl-N-methyltryptamine (5-MeO-MiPT) as the representative drug for NPS, and found that, 5-MeO-MiPT led to obvious...
Ecotoxicology and Environmental Safety
January 31, 2024
Sen Zhao, Jinyuan Chen, Chenhao Zhong et al.
3 citations
5-Methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) is a novel psychoactive substance exhibiting a tryptamine structure. Despite its increasing prevalence, the environmental impact of 5-MeO-MiPT remains unexplored. Our prior investigation revealed that 5-MeO-MiPT induced inhibited spontaneous movement and prompted anxiety-like behavior in adult zebrafish-a validated toxicological model. To...