Biological Psychiatry
February 3, 2026
Mehmet Bostancıklıoğlu, Davut Sinan Kaplan, Ramazan Bal et al.
Psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) produce rapid, enduring therapeutic effects in post-traumatic stress disorder (PTSD); however, the underlying cellular mechanisms remain incompletely understood. This study investigated whether adult myelin plasticity contributes to the therapeutic actions of psilocybin and MDMA in a rat model of contextual fear conditioning. Adult male...
Psychedelics
February 3, 2026
Sheida Shadani, Erika Greaves, Zane B. Andrews et al.
Psychedelics, particularly psilocybin, have shown therapeutic potential across several psychiatric conditions, including depression, anxiety, obsessive-compulsive disorder, and anorexia nervosa (AN). These disorders often share social deficits that may be effectively alleviated by psychedelics considering their use has been linked with emotional empathy and enhanced social cognition. However,...
Neurology and Neuroscience
February 2, 2026
W. Krömer
The present opinion article first discusses the fundamental basis of self-consciousness (self-awareness).The biological situation is then compared to artificial systems. Actually, the deficiencies of artificial systems will highlight the key features of biological systems. Biological self-consciousness requires an individual to whom something can become conscious, which basically depends on the...
Psychopharmacology
February 2, 2026
Benjamin Anderson, Andrew Winokur, Grace J Chan
1 citation
Major Depressive Disorder is a common and disabling psychiatric illness whose pharmacological treatment options have historically been characterized by relatively low response rates. "Treatment-resistant depression" has emerged to describe patients whose depressive symptoms fail to respond to multiple courses of oral antidepressant medications. In 2019, the FDA approved intranasal esketamine as...
Neuropsychopharmacology
February 2, 2026
Maya C Gaines-Smith, Justin M Silverman, Michael Fiorillo et al.
3 citations
The psychoactive entactogen 3,4-methylenedioxymethamphetamine (MDMA), widely known as a recreational drug, is gaining renewed attention as a potential psychotherapeutic adjunct for treatment-resistant psychiatric disorders, yet its neurobiological mechanisms - particularly those related to its stereoisomers and sex-specific effects - remain poorly understood. Here, we report stereoselective and...
Psychiatry Research
February 2, 2026
Tatiana Aboulafia Brakha, Albert Buchard, Cédric Mabilais et al.
1 citation
Classic serotonergic psychedelics such as LSD and psilocybin show promising antidepressant effects in controlled trials, but real-world data from routine clinical care remain limited. This study retrospectively analysed routine data from adults with treatment-resistant depressive and/or anxiety disorders who received a first standardized Psychedelic-assisted Psychotherapy (PAP) cycle with 100...
Clinical Psychology Review
February 2, 2026
Jolien K E Veraart, Nina Schimmers, Joost J. Breeksema et al.
4 citations
Ketamine-assisted psychotherapy (KAP) is considered a promising treatment strategy in psychiatric disorders, combining psychotherapeutic interventions with the rapid-acting pharmacological effects of ketamine towards enhancing outcomes. Although KAP has been practiced for many years across different diagnoses, evidence regarding optimal treatment methods and working mechanisms remains limited...
JOURNAL OF ADVANCE AND FUTURE RESEARCH
February 1, 2026
Baby Sebastian Mundakkttu
The Mundakkttu Scale-Dependent Emergent Law (SDEL) Theory proposes a unified conceptual framework for understanding reality across physics, mathematics, life, consciousness, and ethics through a single foundational principle: interaction. The theory argues that laws of nature are not eternal or universal entities, but emergent, scale-dependent regularities arising from stable patterns of...
Arthroplasty today
February 2026
Jessica L H Phillips, Makenna R Hemmerle, Roseann M Johnson et al.
Sleep quality declines in the immediate postoperative period following total knee arthroplasty (TKA). No prior study has prospectively analyzed the impact of mindfulness meditation (MM) on sleep quality following TKA. The purpose of this study was to determine whether MM administered in conjunction with TKA results in any improvement in Pittsburgh Sleep Quality Index (PSQI) at 2, 6, or 12 weeks...
European Child & Adolescent Psychiatry
February 2026
Konstantinos N Fountoulakis, Paraskevi Tatsiopoulou, Athanasios Saitis et al.
Ketamine and esketamine have been approved as an adjunctive therapy for treatment-resistant major depressive disorder with acute suicidal ideation and behavior in adults. The current paper aimed to systematically review the available data on their efficacy in children and adolescents. The MEDLINE was searched with the keyword 'esketamine' on July 5th, 2024 (by following the PRISMA statement)....