3,4-methylenedioxymethamphetamine (MDMA) is being investigated as a new therapy for post-traumatic stress disorder (PTSD). With antidepressants as the first-line pharmacotherapy for PTSD, it is important to understand any drug-drug interactions between antidepressants and MDMA. This study aimed to investigate the association between antidepressant use and MDMA fatality using a drug-death...
Quality in SportApril 5, 2026Magdalena Ostaszewska, Milena Majchrzyk, Damian Zienkiewicz et al.
Introduction and aim of the study: 3,4-methylenedioxymethamphetamine (MDMA) is a stimulant drug with widespread consumption. It is used mainly in recreational settings, due to its ability to induce various pleasurable, mood-enhancing effects. Prolonged and excessive MDMA misuse can lead to multiple negative outcomes ranging from cognitive dysfunction or emotional dysregulation to severe...
Psychiatric symptoms and existential distress are common at the end of life and associated with poor outcomes. Psychedelic therapies are an emerging option for managing such patients, but their testing and application depends, inter alia , on prescribers’ perspectives. However, no published data exist on the opinions of Australasian palliative care medical staff regarding psychedelic safety and...
This paper develops a neurophilosophical account of rationality by arguing that what is commonly referred to as “reason” does not correspond to a unified or central faculty in the brain. Drawing on contemporary neuroscience, including predictive processing frameworks, distributed models of valuation, and prefrontal control systems, the paper shows that cognition emerges from the dynamic...
The effect of cannabis use on health is likely to depend on individual differences. In particular, there is a growing need to understand the impact of cannabis and delta-9-tetrahydrocannabinol (THC) on brain and behavioral health across the lifespan. We conducted a narrative review summarizing the effects of cannabis and THC across three stages of life: in utero, adolescence, and late...
Abstract Background Most substance users are polysubstance users; however, little is known about how the combined use of different drugs affects the course of substance use disorder or effectiveness of treatment. Notably, co-use of cannabis and nicotine is very common, and we previously demonstrated that nicotine enhances the self-administration of a synthetic cannabinoid receptor agonist and...
Medical ImagingApril 1, 2026A. Wismüller, A. Vosoughi, Akhil Kasturi
Functional magnetic resonance imaging (fMRI) in the resting state often involves analyzing thousands of potential connections with only a few hundred time points, presenting a significant challenge in causal modeling and topology inference of brain networks. This study evaluates whether large-scale Granger Causality (lsGC)—which uses principal component analysis and autoregressive modeling—can...
Introduction. Mindfulness has been linked to emotional regulation and well-being, yet its role in emotional creativity and academic achievement remains insufficiently understood. Emotional creativity involves the ability to experience, express, and regulate emotions in novel, effective, and authentic ways, which may be particularly important for university students facing academic and emotional...
BACKGROUND Cannabis use is highly prevalent among people with psychotic disorders. While there is some indication that cannabis use exacerbates psychosis symptoms, its neurocognitive effects remain unclear. Co-use of cannabis and tobacco is increasing in the general population, but little is known about its effects in people with psychosis or those at risk for developing a psychotic disorder,...
This chapter examines cannabis, tracing its historical role in human history, concluding that it is one of humanity’s earliest cultivated plants. The chapter then looks at its use in medicine and rituals across ancient cultures. Globally, cannabis ranks as the most used illicit drug, with usage patterns influenced by factors such as age, gender, and geography. Legal and cultural perspectives...