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Annals of Medicine and Surgery

ISSN 2049-0801

12 papers in the library · 9 citations · publishing 2022-2026

Papers

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Psilocybin-assisted therapy in treatment-resistant depression: rapid remission, uncertain durability, and the next phase of clinical evidence

Annals of Medicine and Surgery June 18, 2026 Astrit Sabani, Adnan Khatak

Treatment-resistant depression (TRD) remains a major clinical challenge and is typically defined as the persistence of depressive symptoms despite at least two adequate antidepressant trials. Individuals with TRD experience substantial morbidity, impaired functioning, and elevated suicide risk, highlighting the need for therapeutic strategies beyond incremental refinements of conventional...

DOI: 10.1097/ms9.0000000000005244 (opens in new tab) Major depressive disorder Treatment-resistant depression Electroconvulsive therapy Dosing +10

Ecstasy (MDMA) for social anxiety in autism: a specialized application of empathogen therapy

Annals of Medicine and Surgery April 6, 2026 Mahnoor Sheikh, Zaibunnisa Bilal, Syeda Habiba Fatima et al.

To the Editor, Autism spectrum disorder (ASD) is a neurodevelopmental state in which there are early emerging problems in social communication along with fixed behavior patterns. Social difficulties in ASD are characterized by difficulty in interpretation of interpersonal signals such as facial expressions, tone of voice, and body language. Individuals with ASD often present with social...

DOI: 10.1097/ms9.0000000000004936 (opens in new tab) Ecstasy Social anxiety Social skills Social inhibition +14

A narrative review on the neurobiology of lucid dreaming: mechanisms and therapeutic potential.

Annals of Medicine and Surgery January 21, 2026 Tirath Patel, Ashfaq Ahmad, Kinza Irshad et al.

Background: Lucid dreaming (LD), which involves being aware of and controlling one’s dreams, is of particular interest in the study of consciousness and has potential therapeutic applications. In this narrative review, we highlight the neurobiological aspects of LD, specifically its mechanisms associated with the activation of prefrontal and parietal areas, increased gamma oscillations, and the...

DOI: 10.1097/ms9.0000000000004741 (opens in new tab) Full text (opens in new tab) Post-traumatic stress disorder Lucid dreaming Neurobiology Rem sleep +1

Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder.

Annals of Medicine and Surgery 2026 Sana Rasheed, Rida Arif, Ahmed Asad Raza et al. 1 citation

Psilocybin, a naturally occurring psychedelic compound, has received attention as a novel therapeutic option for major depressive disorder (MDD), particularly in cases where traditional treatments prove ineffective. The study aims to evaluate psilocybin's therapeutic potential by examining its efficacy, safety, and mechanisms of action as well as addressing the societal and regulatory...

DOI: 10.1097/ms9.0000000000004349 (opens in new tab) Full text (opens in new tab) Major depressive disorder Psilocybin Psychedelic therapy Clinical trials +1

Optimizing ketamine dosing strategies across diverse clinical applications: a comprehensive review.

Annals of Medicine and Surgery July 18, 2025 Ahmed M Kedwany, Reem Sayad, Nada S Jibril et al.

Ketamine has emerged as a versatile therapeutic agent with applications spanning anesthesia, pain management, and psychiatric disorders. This review examines ketamine's clinical utility across diverse administration routes, including intravenous, intramuscular, intranasal, and oral, emphasizing the need to individualize dosing regimens. We explore factors influencing ketamine dosing, such as...

DOI: 10.1097/ms9.0000000000003580 (opens in new tab) Full text (opens in new tab) Depression Ketamine Safety Pain +1

Safety considerations and risk mitigation strategies for ketamine use: a comprehensive review.

Annals of Medicine and Surgery May 1, 2025 Reem Sayad, Ahmed Saad Elsaeidy, Amna M Anis et al. 7 citations

Ketamine, a dissociative anesthetic, has gained widespread use in various medical contexts, including anesthesia, pain management, and treatment-resistant depression. Despite its therapeutic potential, concerns regarding its safety profile have prompted ongoing research and regulatory guidance. This comprehensive literature review explores the current safety considerations of ketamine,...

DOI: 10.1097/MS9.0000000000003232 (opens in new tab) Full text (opens in new tab) Depression Ketamine therapy Mental health treatment Medical safety protocols +2

Assessment of laparotomy-induced stress response in opium- and morphine-addicted rats by measuring serum glucose and corticosterone levels: an animal experiment.

Annals of Medicine and Surgery March 1, 2025 Yeganeh Pakbaz, Sepideh Eydivandi, Ayda Khandani et al. 1 citation

Surgical procedures induce stress responses similar to severe illnesses, activating the metabolic and neuroendocrine systems, especially the hypothalamic-pituitary-adrenal (HPA) axis. The resulting cortisol surge maintains homeostasis but can adversely affect recovery by elevating blood glucose levels and increasing the risk of complications. Given the high prevalence of opium use, especially...

DOI: 10.1097/MS9.0000000000003010 (opens in new tab) Full text (opens in new tab) Animal study Laparotomy Opium Surgical stress response +6

Mystical and mythological believes not only limited to psychiatric diseases? A dynamic overview of medicine.

Annals of Medicine and Surgery February 17, 2023 Anusha Sumbal, Ramish Sumbal

The concept of supernatural forces has always been part of medicine and allied science. These beliefs play a pivotal role in the patient-healthcare bond and disease awareness. Traditionally it was believed that psychiatric illnesses are mostly linked with mythologies and paranormal beings since most mental diseases appear to be lunatic and have no rational ground. Paradoxical to this...

DOI: 10.1097/ms9.0000000000000108 (opens in new tab) Full text (opens in new tab)

Efficacy of mindfulness-based intervention for the treatment of chronic headaches: A systematic review and meta-analysis.

Annals of Medicine and Surgery June 2022 Muhammad Aemaz Ur Rehman, Radeyah Waseem, Ume Habiba et al.

Mindfulness-based stress reduction/cognitive therapy has attained popularity as an adjunctive treatment for a plethora of medical and psychiatric conditions, however, its impact on chronic headaches is inconclusive. This review aims to assess the impact of MBSR/MBCT in alleviating the symptoms of chronic headaches. PubMed and Cochrane CENTRAL were searched from inception till 1st May 2021....

DOI: 10.1016/j.amsu.2022.103862 (opens in new tab) Full text (opens in new tab) Cluster headaches Migraine Mindfulness-based cognitive therapy Mindfulness-based stress reduction +1