The study examined how the different psychological constructs of mindfulness, anxiety, and positive fantasy engagement influence tourist fatigue in digitally mediated tourism experiences. In response to the increasing anxiety regarding cognitive overload in AI-driven travel ecosystems, the study reconceptualizes fatigue as configuration-dependent, but not uniformly experienced. Composite...
Introduction With expanding global cannabis legalization and rising usage rates, elucidating the specific neurocognitive impact of acute cannabis intoxication across biological sexes is critical. Methods Using a 2 × 2 factorial design, we examined 154 adults: 77 individuals who use cannabis regularly (≥ 5 days/week for ≥ 1 year; 46 males, 31 females) and 77 matched controls (32 males, 45...
Consciousness science has made substantial progress in studying how perceptual contents become conscious, yet it has paid comparatively little attention to a broader question: what makes an experiential world feel real? This article treats the sense of reality as a distinct explanandum, understood as the pre-reflective way in which a current world is experienced as present, coherent,...
Scientific ReportsApril 16, 2026Min Seo Lee, Im-Sook Song, Yeonsu Jang et al.
Eutylone is a methylenedioxy-substituted synthetic cathinone increasingly detected in toxicological case analyses and commonly encountered under polydrug use conditions. To support metabolism-informed surveillance and risk assessment of emerging stimulants, this study comprehensively characterized eutylone disposition and interaction liability using plasma protein binding, metabolic stability...
Depression represents a critical global health burden, ranking as the second leading cause of disability worldwide. Although drug therapies remain an important cornerstone in treating depression, we must acknowledge their significant shortcomings: they often take too long to work, cause difficult side effects, and fail to prevent relapse. Critically, while current drugs target specific...
Amidst a growing prevalence of adolescent mental ill-health, there is a pressing need to develop effective therapeutic interventions. Despite promising results from adult trials of psychedelic-assisted therapies (P-AT), translating these interventions to adolescents presents challenges. Therapeutic outcomes in paediatric contexts cannot be inferred from adult studies due to age-dependent...
Abstract Rationale Many cannabis users claim that one reason they use cannabis is to relieve stress or dampen effects of stressful memories. However, the processes by which cannabis or its primary constituent, Δ 9 -tetrahydrocannabinol (THC) alleviate stressful experiences remains unclear. Objective Here, we assessed whether low oral doses of THC reduce emotional or physiological responses to...
Conscious perception in daily life encompasses continuous experience and persistent percepts of visual inputs. However, the temporal dimension of consciousness, specifically neural mechanisms maintaining sustained conscious percepts over time, remains comparatively understudied. Many studies feature either brief stimulus durations or prolonged supraliminal stimuli without inducing an...
Journal of Psychedelic StudiesApril 15, 2026Jean C. Vélez Rodríguez, Yanice Duquesne-Maldonado, Julián M. Hernández Torres et al.
Abstract Background and aims Psilocybin, a psychoactive compound found in fungi commonly referred to as “magic mushrooms,” is consumed for both spiritual and recreational purposes. However, psilocybin use in Puerto Rico remains understudied. This exploratory cross-sectional survey aimed to describe patterns of use, motivations for consumption, explanatory factors, personality traits, and...
Everyday cognition depends on the brain's capacity to shift between sensing the external world and constructing it from memory. To achieve this, large-scale cortical systems must flexibly integrate incoming sensory signals with internally generated representations. Here, we show that this flexibility is reflected in the macroscale architecture of the default mode network (DMN). Using convergent...