Zenodo (CERN European Organization for Nuclear Research)
October 5, 2026
Marcelo Maximiliano Filippin
preprint
Artificial systems are increasingly evaluated with behavioural, computational, and mechanistic indicators of cognitive constructs such as metacognition, self-modelling, global availability, and potentially consciousness. A problem arises when the evaluated system has itself been exposed, in training or deployment, to descriptions of those constructs, to their proposed indicators, and to the...
International Journal of Nursing and Health Sciences
October 1, 2026
N Saraswathi, S Ganga Lakshmi
Alcohol Dependence Syndrome is a major health problem that affects the physical, psychological, social, and emotional well-being of individuals. Patients with Alcohol Dependence Syndrome commonly experience psychological problems such as anxiety, which may adversely affect treatment adherence, interpersonal relationships, quality of life, and recovery. Therefore, effective non-pharmacological...
International Journal of Applied Research
October 1, 2026
Akshay ., N Ramya
Background: Alcohol use disorder (AUD) is a major public health concern in India. Many people in India also use traditional and spiritual practices such as yoga, meditation, Ayurveda, prayer, and religious rituals. However, little is known about how these practices are viewed within formal de-addiction settings. Objective: This study explored how clients and treatment staff in Delhi perceive...
Research Square
September 30, 2026
Merve Mollaahmetoglu, Joy Krecké, Charlie Oldfield et al.
preprint
Abstract Ketamine is known to have anti-depressant effects and is suggested to reduce substance use. However, little is known about the mechanism of these effects. Given evidence from studies in depression of a greater therapeutic effect in those with a family history of AUD, this latter factor was also investigated as a moderating factor. We used data from the KARE trial, a randomised...
medRxiv
September 28, 2026
Celia J. A. Morgan, David Nutt
preprint
In the KARE trial, 96 adults with severe alcohol use disorder, abstinent following detoxification, were randomised in a 2×2 factorial design to 3 weekly infusions of ketamine (0.8 mg/kg) or saline, each combined with mindfulness-based psychological support (PS) or alcohol psychoeducation (PE). We re-expressed the trial data on endpoints acceptable to regulators and compared the most and least...
PhilPapers (PhilPapers Foundation)
September 18, 2026
preprint
This paper proposes the Self-Foundation Model by reconsidering the structure of self-worth and psychological fulfillment through a basic question: Where does a person place the value of the self? External conditions such as approval from others, intimate relationships, social status, occupational success, achievement, and income are important sources of enrichment in life. However, when...
Personality and Individual Differences
September 10, 2026
Soufiane Mouatassim, Stacey Callahan, J. F. Chassagne
We analyzed the associations between dispositional mindfulness, the Big Five personality traits, and social media addiction, while investigating whether dispositional mindfulness acts as a moderator in these relationships. The research sample comprised 692 nonclinical French young adults (18–30 years old). The following measurement tools were used: the Five Facet Mindfulness Questionnaire-Short...
The International Journal of Neuropsychopharmacology
September 9, 2026
Todd M Solomon, Robert Barrow, Daniel R Karlin et al.
Abstract Background Effective and well-tolerated pharmacotherapies for generalized anxiety disorder (GAD), which is one of the most common psychiatric disorders, are needed. Aims & Objectives To determine the dose-response relationship of MM120 (lysergide D-tartrate) in adults with moderate to severe GAD. Method This phase 2b, multicenter, randomized, double-blind, placebo-controlled study...
The International Journal of Neuropsychopharmacology
September 9, 2026
Orla Mallon
Abstract Background Opioid Use Disorder (OUD) is associated with substantial morbidity and mortality, with relapse remaining common despite the availability of opioid agonist and antagonist pharmacotherapies. Scotland continues to experience a disproportionate burden of drug-related deaths relative to other parts of the United Kingdom and Europe, reflecting the ongoing clinical and public...
The International Journal of Neuropsychopharmacology
September 9, 2026
David Erritzøe
Abstract Background Recent clinical and neuroscientific work has revived interest in psychedelic-assisted therapies as promising treatments for a range of psychiatric conditions. Mechanistically, classical psychedelics and atypical agents such as ketamine appear to act as catalysts of neural and psychological flexibility, disrupting entrenched patterns of activity in “stuck” brain networks and...