Substance use disorders represent a significant public health concern in Pakistan, with methamphetamine showing increasing prevalence, particularly among adults. In light of the escalating incidence of methamphetamine-type stimulant (MTS) consumption observed in Pakistan, this research endeavor sought to assess the efficacy of Mindfulness integrated cognitive behavior therapy (MICBT) for...
BACKGROUND AND AIMS: This study qualitatively explored psychological change processes as described by participants and therapists within a phase 2a clinical trial evaluating the safety, tolerability, and preliminary efficacy of a single dose of intranasal 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; BPL-003) administered alongside psychological support and manualised cognitive behavioural...
Psychiatry ResearchAugust 1, 2026C. Bharat, Xin-Tong Huang, G. Campbell et al.
BACKGROUND Interest in cannabinoids for mental and substance use disorders is increasing. We examined experimental and observational evidence for treating these disorders and their symptoms. METHODS Systematic review and meta-analysis (PROSPERO CRD42023467536). We searched CENTRAL, MEDLINE, Embase and PsycINFO to May 2025 for studies of cannabinoids in adults (≥18 years) with ADHD, anxiety,...
Background: Adolescents’ life now revolves around social media, which offers them chances for amusement, education, and communication. But extreme use can effect in social media addiction (SMA), which is marked by obsessive use, lack of control, withdrawal symptoms, and interference with day-to-day activities. Adolescents (ages 10 to 19) are especially vulnerable because of social,...
The present study examined the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) in reducing emotion dysregulation among patients with SUD. A randomized controlled trial with a pre-test and post-test design was conducted at Umeed-e-Shifa Rehabilitation Centre, Bani Gala. Forty male participants aged 20–40 years meeting DSM-5-TR criteria for SUD were selected through purposive sampling and...
Mindfulness is defined as nonjudgmental, nonreactive, metacognitive attention focused on the experience of the present moment, without being caught up in thoughts about the past or future (Garland, 2007). Mindfulness-based interventions are gaining growing interest in the field of clinical psychology. This third-wave cognitive behavioral therapy (CBT) has been shown to be effective in the...
Since the introduction of disulfiram in 1951 (the first ever Food and Drug Administration (FDA)-approved medication for substance use disorders (SUDs)) (1), only seven other individual medications have been approved for the treatment of SUDs. While the repurpose of medications and different formulations increase the total number of FDA-approved medicines (Table 1 and(2)), the arsenal of...
Introduction Substance use disorder (SUD) is a major global health issue, contributing significantly to the disease burden. Despite this, effective treatments for SUD remain limited. Ketamine has shown potential as a treatment, yet no meta-analysis has assessed its efficacy for SUD. This study aimed to evaluate the efficacy and safety of ketamine in treating SUD. Methods Multiple databases were...
Substance use disorders (SUDs) affect the lives of more than 35 million people worldwide, according to 2019 data from the United Nations Office on Drugs and Crime. Current evidence suggests that MBIs may mitigate the harmful psychosocial effects associated with SUDs. Although MBIs have been extensively studied for efficacy, there remains a growing need to synthesize evidence from relevant...