ULAKES JOURNAL OF MEDICINEMay 13, 2026Maria Eduarda Marquezi Machioni, Giulia Argueles de Oliveira, Ana Luísa da Silva Rueda et al.
Diante da crescente prevalência dos diagnósticos de transtornos ansiosos no Brasil e no mundo, o presente artigo visa analisar as contribuições das substâncias psicodélicas no tratamento dos transtornos. Por meio de uma revisão narrativa, foram examinados estudos sobre o potencial terapêutico de compostos como LSD, psilocibina, ayahuasca e MDMA. Os resultados colhidos apontam que essas...
Psychedelics have emerged as powerful modulators of neural plasticity, yet whether the atypical psychedelic ibogaine can enhance plasticity remains poorly understood. Here, we investigated whether a single administration of ibogaine can reinstate juvenile-like experience-dependent plasticity in the adult mouse visual cortex, a canonical model for studying neuroplasticity. Adult mice were...
Zusammenfassung Substanzkonsumstörungen (SUD) sind chronische Erkrankungen mit hohen Rückfallraten und begrenzter Wirksamkeit etablierter Behandlungen. Vor diesem Hintergrund rückt die psychedelisch-assistierte Psychotherapie (PAP) mit Psilocybin und LSD zunehmend in den Fokus; die Literatur berichtet Hinweise auf mögliche Effekte insbesondere bei AUD und affektiven Symptomen. Ziel der Studie:...
One recurrent source of religious and mystical appearance lies in the way finite motifs resist finite closure and come to be inhabited under maximal, unconditioned, or unsurpassable forms. We call these forms limit-forms and argue that they are Husserlian horizonality under existential pressure: ordinary experience always exceeds what is presently given, but some horizons become...
Much of a typical individual's mental life is characterized by spontaneous thoughts that occur independently of external stimuli. In prior studies, ongoing mental experiences and their neural correlates have been captured using thought probes presented at random intervals during functional Magnetic Resonance Imaging (fMRI). However, this approach results in temporally imprecise estimates of...
BACKGROUND: Preliminary evidence examining ibogaine in neuropsychiatric and substance use disorders is accumulating. As patient interest and off-label use grow, clinicians require an understanding of emerging dosing strategies, investigational protocols, and reported adverse effects to appropriately counsel patients and contextualize potential risks and benefits. METHODS: Databases were...
Scientific ReportsMay 11, 2026Salman Khan, Minseo Baek, Jeong-Hoon Jang et al.
Synthetic cannabinoid receptor agonists constitute a prominent class of new psychoactive substances (NPS), in which minor structural modifications can markedly influence in vivo pharmacological outcomes. In this study, methoxy-substituted derivatives of JWH-018 were synthesized to examine the effect of substitution position on behavioral activity. JWH-018–5-OMe and JWH-018–6-OMe were evaluated...
Recent debates within mindfulness in education in the United Kingdom highlight tensions between instrumental and integral approaches. Large-scale evidence from the University of Oxford’s MYRIAD project has questioned the effectiveness of school-based mindfulness in preventing adolescent mental health problems, while revealing positive impacts on teachers’ wellbeing and school climate. This...
Abstract Objectives Focused attention (FA) and open monitoring (OM) are distinct mindfulness practices that produce unique psychological effects. Prior research has frequently investigated the neural correlates of FA and OM states utilizing electroencephalographic (EEG) methods, focusing on changes in spectral power within theta and alpha bands. Yet the functional significance of these neural...
NeuropsychopharmacologyMay 9, 2026Ana Maria Raymundi, Nathalie Carla Cardoso, Gabriel Costa Lourenço et al.
In PTSD, microglia are more engaged in fear-related circuits, where they participate in fear memory processing responses. The reconsolidation-impairing effect of Δ⁹-tetrahydrocannabinol (THC), the primary psychoactive constituent of Cannabis, is typically linked to cannabinoid type-1 receptor (CB1) signaling. THC also engages peroxisome proliferator-activated receptor gamma (PPARγ), and both...