PharmaceuticalsMay 31, 2026Wenting Zhang, Xin Guo, Jiping Zhang et al.
Background: Ketamine is a rapid-acting antidepressant for major depressive disorder; however, its effects are short-lasting and associated with neurotoxic side effects. Thus, identifying strategies to prolong its antidepressant effects is of critical importance. It has been shown that Dajianzhong Decoction (DJZT) prolongs the antidepressant effects of ketamine through modulation of the gut...
SUBJECT & OBJECTIVES: Contemporary emerging spirituality is derived from spirituality in postmodern conditions, moving beyond the era of modernity toward a form of spirituality without religion. Thus, the formation of contemporary emergent spirituality arises in response to the spiritual deficiencies of modernity, characterized by a pursuit of tranquility, accommodation to existing...
Biomedical models have substantiated particularly the ineptness at communicating bipolar disorder as a lived cognitive and affective experience․ This research contemplates the graphic memoir Marbles: Mania‚ Depression‚ Michelangelo‚ and Me 24) by Ellen Forney to be a cognitive-phenomenological archive of bipolar disorder where the text not only enacts but represents mania and depression in...
Description: Meaning, Alternatives, and the Adjudicative Function Core question: Why does recognized error feel qualitatively different from ordinary failure? Central claim: A system can only be wrong if alternatives existed. Meaning itself depends on the maintained possibility of relating distinctions in more than one way. Cognition therefore includes a distinct function — the adjudicative...
Os transtornos psiquiátricos representam importante problema de saúde pública mundial, frequentemente associados a elevada morbidade, incapacidade funcional e impacto significativo na qualidade de vida. Apesar dos avanços terapêuticos disponíveis, muitos pacientes permanecem refratários aos tratamentos convencionais, estimulando a busca por novas abordagens terapêuticas. Nesse contexto, os...
PsychedelicsMay 30, 2026Vinicius Ryu Kami, Beatriz Borges Bueno Salle, Giovanni Porto et al.
Background Contemporary psychiatry is associated with several challenges, including limited remission rates in complex and severe psychiatric disorders. In this context, psychedelics have re-emerged globally as a promising therapeutic paradigm. Brazil occupies a unique position in this scenario, mainly due to the legal protection and cultural integration of Ayahuasca, which fosters a distinct...
The κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive. Here, we demonstrate stable κOR dimer formation in living cells and present cryo-electron microscopy structures of salvinorin A-bound κOR dimer complexed...
Trauma-related distress in adult women often extends beyond posttraumatic stress disorder (PTSD) to include depressive symptoms and dissociation, yet the roles of mindfulness and self-compassion across these symptom domains remain insufficiently clarified. This study examined mindfulness and self-compassion as psychological resources associated with trauma-related symptoms among trauma-exposed...
A central unresolved question in computational consciousness research concerns whether meaningful differences between biological and artificial systems can be quantified without recourse to computationally intractable measures such as Integrated Information Theory (IIT). We propose Participation Ratio (PR) — derived from the eigenvalue distribution of neural trajectory covariance matrices — as...
This study examined mindfulness and spirituality as potential explanatory mechanisms underlying the associations between connection to nature and young adults’ psychological wellbeing (depression, anxiety, perceived stress, life satisfaction, and positive states of mind). Two studies employed structural equation modeling (SEM) to test these pathways using different conceptualizations and...