Postoperative hallucinations and other psychotropic effects are known side effects, which may be dose-dependent. Higher doses exacerbate these changes, prolonging dissociative and hallucinatory experiences postoperatively. The study aimed to evaluate the effect of ketamine different doses on postoperative hallucination (score and types). This study was applied on (62) persons including (32)...
Introduction: Nitrous oxide (N2O) abuse is a growing international concern, with limited effective intervention strategies. This study investigates the potential of Cryptotanshinone (CTS) and its metabolite tanshinone IIA (TAN IIA) in alleviating N2O-induced conditioned place preference (CPP) behavior and modulating dopamine D1 receptor (D1R) and TrkB pathway Methods: In vivo, a CPP mouse model...
Depersonalization is usually reported as a manifestation in other psychiatric disorders such as psychosis, anxiety, or depression; in physical trauma; or in drug addiction. But it has been very little reported in clinical descriptions relating to bodily injuries such as diabetic foot. This article focuses on the case of four Cameroonian adults with diabetic foot and presenting clinical...
Background. Music performance anxiety and musculoskeletal disorders can lead to devastating outcomes for musicians, such as career abandonment and substance use. This thesis uses functional Magnetic Resonance Imaging (fMRI) to investigate the neurobiological mechanisms through which mindfulness-based and somatic interventions may improve musicians’ health and well-being. Studies 1 and 2...
Methamphetamine (METH, "Crystal Meth") and 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are two types of substituted amphetamines that share structural-chemical similarities but exhibit contrasting acute and chronic effects including addictive liability. Tryptophan (TRY) pathways are involved in pleiotropic physiological functions at the interface of brain-body connections. Preclinical...
Psychedelics are seeing renewed interest due to their potential as therapeutic tools; however, despite promising clinical findings, the underlying signaling mechanisms and brain-region specific effects of psychedelics remain unclear. This dissertation first describes a comprehensive study aimed at understanding the on and off-target actions of ~40 diverse psychedelic substances representing...
PsiConnect is a large-scale neuroimaging study designed to investigate context-dependent neural and subjective effects of psilocybin using multimodal neuroimaging. It combines functional, structural, and diffusion-weighted MRI with EEG to examine brain activity in 62 participants before and after a 19 mg dose of psilocybin. The design includes resting-state scans and three naturalistic...
Mescaline, a 5-HT2A agonist psychedelic used ceremonially for millennia, lacks neuroimaging characterization due to its Schedule 1 status. Using pharmacological and resting-state fMRI in awake rats, we report mescaline's first comprehensive neurobiological profile. Acutely, mescaline produced cerebellar-selective BOLD suppression, suggesting functional disconnection from forebrain structures....
May 20, 2026I. Ivlev, M. Pappas, Tamara P. Cheney et al.
Objective. To evaluate the effectiveness of mindfulness-based interventions (MBIs) and Acceptance and Commitment Therapy (ACT) for mental health and well-being of children and adolescents with and without anxiety, depression, and chronic health conditions. Data sources. Ovid MEDLINE, PsycINFO, Cochrane Library, and ERIC (2009-April 21, 2025); reference lists of relevant reviews. Review methods....
Neuroplastogens, small molecules that induce beneficial neuronal growth and plasticity, are a class of compounds emerging as new drugs for treating a range of central nervous system conditions. Clausenamide is a plasticity-promoting natural product isolated from the leaves of Clausena lansium, an evergreen native to Southeast Asia and southern China. Herein, we report an efficient synthesis of...