Serotonergic psychedelics are known for their profound effects on consciousness and are gaining renewed interest as potential psychiatric treatments. These advances underscore the need to clarify the mechanisms of action of these compounds. This systematic review compiles and critically evaluates 23 in vitro and 26 in vivo electrophysiological studies on psychedelic compounds, with an emphasis...
BACKGROUND: Several recent trials indicate positive effects of psilocybin in patients with major depressive disorder. However, questions need to be addressed regarding the relationship between dosage and therapeutic outcomes, such as the recommended dose range and frequency for optimal practice as well as the dose-dependent adverse effects. OBJECTIVE: (1) to assess the effectiveness and...
medRxivJune 1, 2026Erica J. Li, Basmah Mosharraf, Hiba Ali et al.
preprint
Background: Psychedelics are emerging as potential management options for chronic musculoskeletal pain due to preliminary evidence of effectiveness and low addictive potential, but patients’ perceptions remain unknown. This study assessed patient perceptions regarding psilocybin for musculoskeletal pain. Methods: We conducted a cross-sectional survey of adults (≥19) with musculoskeletal pain...
Psychedelic-assisted psychotherapy has demonstrated efficacy in treating individual mental health conditions such as addiction, anxiety, depression, and post-traumatic stress disorder. However, current research predominantly focuses on individual experiences, overlooking the relational and systemic factors that influence healing and long-term therapeutic outcomes. This conceptual article...
Clinical trials suggest that a single dose of psilocybin may be an effective treatment for substance use disorders. Choice impulsivity is a value-based decision-making bias that predicts drug-intake escalation and is commonly associated with substance use disorders. The dorsomedial prefrontal cortex regulates choice impulsivity and is enriched with 5-HT2A receptors that mediate effects of...
Brain waves are ubiquitous phenomena of human brain activity. As they propagate, they coordinate neural communication, shaping conscious perception. Understanding how brain waves unfold across space and time is thus critical for uncovering the neural mechanisms that support and suppress consciousness. Here, we analyzed data from the Human Connectome Project alongside multiple independent human...
There has been an increasing interest in the use of classic psychedelics (such as psilocybin) and 3,4-methylenedioxymethamphetamine (MDMA) for treating mental health conditions. Individuals often describe psychedelic sessions as among the most significant experiences in their lives, emphasizing the sense of awe, connectedness, and spiritual transformation taking place. While the psychedelic...
As intervenções baseadas em mindfulness vêm sendo adotadas e têm demonstrado efetividade na melhora das condições crônicas. Esta pesquisa avaliou a efetividade de um protocolo brasileiro de mindfulness para promoção da saúde (MBHP), nos formatos presencial – controle (PC) e intervenção (PI) – e on-line – controle (OC) e intervenção (OI) – no estado nutricional, comportamento alimentar e estilo...
A central unresolved question in computational consciousness research concerns whether meaningful differences between biological and artificial systems can be quantified without recourse to computationally intractable measures such as Integrated Information Theory (IIT). We propose Participation Ratio (PR) — derived from the eigenvalue distribution of neural trajectory covariance matrices — as...
Advances in Brain-computer interfaces (BCIs) have intensified debates about their alleged capacity to read minds and the implications for mental privacy. Prevailing accounts often assume that brain data can reveal inner mental states, framing privacy as a matter of data protection. Yet experimental demonstrations, such as PIN decoding or semantic reconstruction, show that successful decoding...