International Journal of Innovative Science and Research Technology
August 20, 2026
Jay Alfred
This paper develops an ontology in which consciousness is fundamental, and materialism is a boundary condition. Elementary particles in matter possess proto‑consciousness comparable to mass, spin, or charge. In this view, consciousness does not arise from matter; matter is a condensed phase of consciousness, and different degrees of consciousness manifest only when quantum coherence is present...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
August 20, 2026
Charalampos L. Kandilakis, Costas Papatheodoropoulos
Psychedelic-assisted therapy has emerged as a promising therapeutic approach across several psychiatric disorders, yet the mechanisms linking acute brain-state changes and subjective experience to sustained clinical improvement remain incompletely understood. Here, we extend a previously proposed excitation/inhibition (E/I)-centred dual-phase model of psychedelic action to the therapeutic...
Lynchburg Journal of Medical Science
August 20, 2026
Rachel N Clark
The purpose of this review is to evaluate the possible benefits of using psilocybin (C12H17N2O4P), a naturally occurring psychoactive compound found in certain species of mushrooms, in the treatment of multiple forms of mental illness and substance use disorders, either as monotherapy or in conjunction with traditional psychiatric medications. The compound has high affinity for several...
Philosophy and Phenomenological Research
August 19, 2026
Samuel Kimpton‐Nye
In this paper, I argue that the thoroughly algorithmic nature of current AI systems (such as LLMs) is no obstacle to their being conscious, despite strong apparent reasons to the contrary. To this end, I present a picture on which algorithmic AI systems comprise dispositional properties that realize categorical phenomenal properties where the latter, in turn, provide the identity conditions for...
bioRxiv
August 19, 2026
D. Momi, Yasmeen Nahas, D. Wyrick et al.
preprint
Psilocybin produces rapid and lasting therapeutic effects, yet how 5-HT2A receptor activation reshapes brain-wide circuit dynamics during acute drug administration remains poorly understood. Using simultaneous multi-region Neuropixels recordings of 46,360 single units from 35 mice, together with scalp electroencephalography (EEG), pupillometry, and locomotion monitoring, we provide a...
Frontiers in Psychiatry
August 19, 2026
Jeni Page, Alexandra Moore, Bridget E. Hawkins et al.
IntroductionMicrodosing psilocybin magic mushrooms (MM) and truffles has grown in popularity, but the evidence supporting reported benefits remains poorly characterized. The purpose of this systematic review was to synthesize the existing literature on microdosing psilocybin MM and truffles in adults to determine reported health effects and perceived benefits, motivations for use, dosing...
European Journal of Pharmacology
August 18, 2026
Sumin Ban, Kyung Oh Jeon, Su Yeon Seo et al.
3-Fluorophenetrazine (3F-phenetrazine) is a novel amphetamine-like substance that is structurally similar to phenmetrazine and 3F-phenmetrazine. Despite the emergence of 3F-phenetrazine in recreational drug markets, its neuropharmacological profile and abuse liability remain poorly characterized. This study is the first to investigate the psychostimulant, rewarding, and reinforcing properties...
Psychosis
August 18, 2026
Tatiana Baxter, Sohee Park
Felt presence (FP) involves sensing another social entity nearby without clear, corresponding evidence. Characteristics of FP depend on context. Previous work suggests FP is meaningful and welcomed in spiritual practice, but in psychotic-like states, FPs are intrusive, distressing, and intense. However, real-world contexts are rarely so discrete. A total of 337 participants completed an...
August 18, 2026
George Webster
Recent discussions of QBism have turned increasingly toward the question of its ontology. I argue that key insights into QBism's ontology of agency can be identified by reconstructing its response to Wigner's friend paradox. I clarify the relation between two formulations of that response: one grounded in the claim that quantum states are agents'personal probability assignments, and another...
bioRxiv
August 18, 2026
preprint
Brain dynamics exhibit scale-dependent reversibility during consciousness transitions