Current Addiction Reports
August 18, 2026
Michael J. Broman, Jhuma N. Acharya, Kaltum Ahmed et al.
Abstract Purpose of Review We highlight key findings and methodological issues from recent research on the abuse liability of classic psychedelics, utilizing a GRADE to assess the quality of the evidence. Recent Findings Studies using various designs suggest that classic psychedelics (e.g., psilocybin, LSD) have low abuse potential and less dependence liability than other drugs. However, public...
Zenodo (CERN European Organization for Nuclear Research)
August 17, 2026
Karel Hrubec
preprint
Before a Marker Becomes a Mechanism develops an adversarial synthetic falsification framework for evaluating dynamical markers in consciousness research before they are granted strong mechanistic interpretation. The study emerged from the progressive failure of its own candidate mechanism. An initial three-step causal-closure metric failed to capture longer directed loops. A generalized...
Frontiers in Psychiatry
August 17, 2026
Balázs Barko, Szabolcs Kéri
Introduction: Neuronal mechanisms of motion perception are susceptible to developmental anomalies. We tested whether heavy adolescent cannabis use is associated with enduring deficits in global motion perception, with relative sparing of global form perception, in abstinent adults. Methods: In a cross-sectional study, 130 adults were enrolled: cannabis-naïve controls (n=50), non-heavy...
Zenodo (CERN European Organization for Nuclear Research)
August 17, 2026
Parag Garg
preprint
Debates over whether consciousness is computational often leave the proposed computation unclear. This paper separates five phenomena that are regularly run together: intelligence, conscious deployment, the composite sensory movie, selfhood and qualia. Discrimination, prediction and control can proceed automatically, so intelligence alone is not enough. The theory identifies consciousness with...
Zenodo (CERN European Organization for Nuclear Research)
August 17, 2026
Satya P. Dubey
preprint
The rapid advancement of artificial intelligence has raised a foundational question in contemporary cognitive science: can an artificial information-processing system become genuinely conscious? The Illusion of Conscious AI (ICAI) Framework challenges the inference that increasingly sophisticated information processing, intelligence, language generation, self-modeling, behavioural competence,...
August 17, 2026
Tychique T. Wasolua, Morgan S. Hardy, Tanner J. Bommersbach et al.
INTRODUCTION: Approximately 30-40% of patients with major depressive disorder fail to respond to conventional antidepressants. Ketamine and esketamine are increasingly used, yet synthesized data on cumulative safety remain limited. This systematic review evaluated long-term safety of both agents. METHODS: MEDLINE, PsycINFO, Embase, and Cochrane Library were searched from inception through...
August 16, 2026
Morten Overgaard, Martin Dietz, Peter Thestrup Waade
preprint
Scientific theories of consciousness are typically evaluated by comparing empirical findings across experimental paradigms. Such comparisons implicitly assume that different paradigms provide commensurable evidence and do not systematically favour particular theoretical interpretations. Here, we test this assumption using the updated ConTraSt database, comprising 518 published consciousness...
arXiv Preprint Archive
August 16, 2026
Ryota Kanai
preprint
Global workspace theory explains conscious access as the broadcasting of selected information to the rest of the network, but it lacks a formal criterion for identifying the mechanism that enables this access. We propose that a global workspace is a mediator, namely, a subnetwork that receives activity from distributed systems, transforms it through internal modes, and returns differentiated...
Zenodo (CERN European Organization for Nuclear Research)
August 15, 2026
Diogenes Simoes
preprint
This article proposes the concept of Learned Synthetic Rationality Entity (LSRE) as a classificatory category for non-biological entities whose functional rationality is constituted through artificial processes of learning and training, becomes relatively stabilized in its inferential dispositions, and is instantiated in an artificial system. The proposal distinguishes rationality from...
Journal of Affective Disorders
August 15, 2026
Michał Walaszek, Wiesław Jerzy Cubała, Zofia Kachlik et al.
Anhedonia, a core symptom of major depressive disorder (MDD), is associated with illness severity, suicide risk, poor functioning, and predicts poor response to antidepressants. While no treatments are approved, ketamine and esketamine show promise in reducing anhedonia. This study examines clinical and sociodemographic features linked to anhedonia treatment response in treatment-resistant...