International Journal of Molecular Sciences
October 20, 2026
Thainá P Souza, Andrés Rodríguez-Vega, A. C. Dutra-Tavares et al.
Schizophrenia and nicotine misuse comorbidity frequently emerges during adolescence. Although the dorsal striatum has received less attention than mesolimbic regions in this context, growing evidence supports its involvement in both schizophrenia-related dysfunction and the transition to compulsive drug-seeking. Here, we investigated dorsal striatal proteomic alterations in adolescent male and...
Brain Sciences
August 25, 2024
Ana Carolina Dutra-Tavares, Luciana Araújo Couto, Thainá P Souza et al.
Tobacco consumption in schizophrenia (SCHZ) patients is highly prevalent. Data support the occurrence of sequential events during comorbidity establishment, and both smoking first, SCHZ second and SCHZ first, smoking second sequences have been proposed. To investigate whether these two possibilities lead to distinct outcomes of comorbidity, we used a phencyclidine-induced SCHZ model and...
Psychopharmacology
October 1, 2023
Ana Carolina Dutra-Tavares, Thainá P Souza, Juliana O Silva et al.
Sex-biased differences in schizophrenia are evident in several features of the disease, including symptomatology and response to pharmacological treatments. As a neurodevelopmental disorder, these differences might originate early in life and emerge later during adolescence. Considering that the disruption of the glutamatergic system during development is known to contribute to schizophrenia,...
International Journal of Molecular Sciences
September 27, 2023
Andrés Rodríguez-Vega, Ana Carolina Dutra-Tavares, Thainá P Souza et al.
Tobacco misuse as a comorbidity of schizophrenia is frequently established during adolescence. However, comorbidity markers are still missing. Here, the method of label-free proteomics was used to identify deregulated proteins in the medial prefrontal cortex (prelimbic and infralimbic) of male and female mice modelled to schizophrenia with a history of nicotine exposure during adolescence....