Journal of Studies on Alcohol and Drugs
May 28, 2026
Cassidy R Loparco, Matthew E Rossheim, Kayla K Tillett et al.
Retail sales of intoxicants, including derived intoxicating cannabis products (DICPs) such as delta-8 tetrahydrocannabinol (THC) and hallucinogenic mushrooms, have rapidly increased throughout the US, despite their sale being federally illegal. This study assessed DICP and hallucinogenic mushroom availability in US smoke shops with differing DICP and psilocybin laws. In May-October 2025, using...
Frontiers in Psychology
May 28, 2026
Lidia Venero-Hidalgo, Francisca Carvajal, Fernando Rodrı́guez de Fonseca et al.
Introduction: Cannabis use during adolescence and young adulthood has been associated with neurocognitive alterations. However, limited attention has been paid to whether these findings vary according to developmental stage and regional context. This systematic review examined the neurocognitive effects of cannabis use in adolescents and young adults, with particular attention to age-related...
Drugs Habits and Social Policy
May 27, 2026
Estelle Miller, David B Menkes, Suresh Muthukumaraswamy et al.
Purpose Current laws prohibiting access to illicit drugs contribute to drug harms as manufacturers and distributors of illicit substances have variable influence over drug supply and quality. Legislation introduced in New Zealand (NZ) in 2021 aimed to address such harm by enabling licenced drug checking providers to directly analyse samples from consumers. This paper aims to detail the use of...
May 27, 2026
Jonathan Lamb
Cannabis continues to be the most widely used illicit drug, usually used recreationally without significant problems occurring. Concerns remain over long term health of users and the possibility of associations with mental illness. Surveys suggest regular use remains common amongst teenage males, taking place concurrently with the period when teenagers are engaged in identity development and...
Frontiers in Pharmacology
May 26, 2026
Michal Ordak
The rapid evolution of the novel psychoactive substances market has blurred the boundaries between synthetic “designer drugs” and other emerging psychoactive products distributed outside traditional regulatory frameworks. Recently, increasing recreational and self-therapeutic interest in Amanita muscaria has led to its growing presence within the broader landscape of substances used in patterns...
Neuroscience
May 25, 2026
Caitlyn C Costa, Aoife S Weiss, Caroline M Limbaker et al.
Rates of cannabis use continue to rise, however, the neurocognitive effects are not fully characterized. Deficitsin memory processes, especially in adolescents, have been reportedfollowing exposure toΔ9-tetrahydrocannabinol (THC), the main psychoactive componentin cannabis. Treatments addressing these deficits have been unsuccessful. Here, we test the hypothesis that vaporized THC/cannabis...
Physiological research
May 12, 2026
Marcel Bochin, Čestmír Vejmola, Vlastimil Koudelka et al.
Cannabinoids modulate brain network activity, yet the spatial organization and temporal evolution of their electrophysiological effects remain insufficiently characterized in animal models. Here, we investigated how acute oral administration of ?9-tetrahydrocannabinol (THC; 10 mg/kg), cannabidiol (CBD; 10 mg/kg), and their combination influences resting-state EEG dynamics in freely moving rats....
American Journal of Preventive Medicine
May 4, 2026
Kevin H. Yang, Nora Satybaldiyeva, Wayne Kepner et al.
1 citation
IntroductionMicrodosing involves consuming low doses of psychoactive substances, typically between 1/5th and 1/20th of a recreational dose. Despite increasing public attention to cannabis and psychedelics amid evolving drug policies, epidemiologic data on microdosing remain limited.MethodsA cross-sectional, web-based survey (Characterizing the Epidemiology of Cannabidiol Use Survey) of 1,523...
European journal of pain (London, England)
May 1, 2026
Michael M Morgan, Christa M. Hickey
Many people use cannabis to self-medicate for pain. Little is known about the impact of pain on tolerance and spontaneous withdrawal to delta-9-tetrahydrocannabinal (THC), the primary psychoactive compound in cannabis. Our previous research with the opioid morphine suggests persistent pain will increase the magnitude and duration of THC withdrawal. Male and female Sprague-Dawley rats were...
Psychopharmacology
May 1, 2026
Catherine F Moore, Elise M Weerts
Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and for developing medications for Cannabis Use Disorder. Use of vapor inhalation models have translational relevance, as the majority of humans who use cannabis do so by inhalation (e.g., smoking, vaporization). Adult male and female Sprague Dawley rats (N = 96,...
JAMA Network Open
May 1, 2026
C Austin Zamarripa, Spencer Lin, Mckenna Klausner et al.
Simultaneous cannabis and alcohol use (co-use) is a public safety concern. Controlled data on the effects of co-ingestion of oral cannabis products (edibles) with alcohol are lacking, despite an increased prevalence of this behavior. To evaluate the individual and interactive effects of cannabis edibles and alcohol on simulated driving and subjective and objective impairment measures. This...
Brain, behavior, and immunity
May 1, 2026
Havilah P Ravula, Barkha J Yadav-Samudrala, Laith E Sawaqed et al.
Δ9-tetrahydrocannabinol (THC) has been studied for its neuroprotective benefits in disease and its ability to improve HIV-1-related symptoms in clinical and preclinical models. Chronic THC administration may cause reduced sensitivity to antinociceptive, hypothermic, and anxiolytic effects following acute THC administration, and HIV status may further influence these effects. Thus, the present...
Biological psychiatry. Cognitive neuroscience and neuroimaging
May 1, 2026
Zachary Anderson, Matthew Gunn, Emily Jones et al.
Cannabis use among young adults has reached the highest levels ever recorded. Evidence indicates that acute Δ9-tetrahydrocannabinol (THC) disrupts brain connectivity. Few studies have examined this on a whole-brain level. We examined the effects of a single moderate dose of THC on resting-state functional brain networks among young adult cannabis users. In a within-subject, double-blind,...
Sleep
May 1, 2026
Denise C. Vidot, Bria-Necole Diggs, Amrit Baral et al.
Abstract Introduction Psychedelic use and interest in its therapeutic potential are rapidly increasing; yet its relationship with insomnia remains poorly understood. This study aims to estimate differences in insomnia severity by type of psychedelic consumed among a cohort of 18-to-35-year olds. Methods Data are from the Herbal Heart Study - Sleep Ancillary (N=100) cannabis consumers....