Chaos Solitons & Fractals
May 30, 2026
Tales Ramos Monteiro Dos Santos, Draulio B Araujo, Helcio Felippe et al.
Psychedelic states offer a useful setting for studying changes in large-scale brain organization. Here, we applied Topological Data Analysis (TDA) to resting-state fMRI functional connectivity from nine participants scanned before and after Ayahuasca ingestion. Vietoris–Rips filtrations were constructed from correlation-derived dissimilarity matrices, and persistent entropy was used to quantify...
Journal of Advances in Medicine and Pharmaceutical Sciences
May 24, 2026
Fernando Benevenuto, Iscia Martha Franco, Antonio Eizirik et al.
Addiction remains a major neuropsychiatric challenge, with dopaminergic, serotonergic, and GABAergic dysregulation underlying maladaptive behaviors. Traditional Brazilian medicinal plants offer a rich source of neuroactive compounds, yet their multi-target mechanisms remain underexplored. This study aimed to evaluate the neuropharmacological potential of harmine, caffeine, and damianin through...
Zenodo (CERN European Organization for Nuclear Research)
May 21, 2026
Elliot Allan
This Zenodo record holds the preprint manuscript, dataset, analysis code, ancillary process-archaeology catalogues, and the full pre-submission audit trail for an ethnobotanical synthesis study evaluating when traditional psychoactive plant knowledge tracks pharmacological reality. The paper addresses three quantitative tests of psychoactive ethnobotanical claims: (i) Cross-cultural comparison...
Revista Ibero-Americana de Humanidades, Ciências e Educação
May 20, 2026
Maysa Cruz Lima Feitosa, Bernardo Melo Neto, Joubert Aires de Sousa
A ayahuasca é uma bebida de origem tradicionalmente indígena, sua preparação resulta da associação de duas espécies vegetais principais: Banisteriopsis caapi, rica em alcaloides β-carbolínicos (harmina, harmalina e tetrahidro-harmina), e Psychotria viridis, que contém a N,N-dimetiltriptamina (DMT). Essa combinação promove efeitos psicotrópicos característicos devido à inibição da monoamina...
Psychedelics
May 16, 2026
Nádia Valéria Moreira Santos, Cristiane Ferreira Silveira, Camila Gutieres Dos Santos Soares Costa et al.
Aim This study aimed to explore the experiences and perceived effects of ayahuasca ceremonies on suicidality. Method We conducted in-depth qualitative interviews with nine participants from the North and Southeast regions of Brazil. These participants were part of a larger cohort and were selected to explore their perspectives on how ceremonial experiences with ayahuasca in neoshamanic contexts...
DIGITAL.CSIC (Spanish National Research Council (CSIC))
May 12, 2026
Javier Calleja‐conde, Víctor Echeverry‐alzate, Marina Sanz-Sancristóbal et al.
Parkinson's disease is a progressive neurodegenerative disorder with increasing global prevalence, primarily driven by population ageing. A hallmark of the disease is the degeneration of nigrostriatal dopaminergic neurons, accompanied by marked activation of glial cells and a sustained neuroinflammatory response. Current pharmacological treatments are limited to symptomatic relief and do not...
Psychedelic Medicine
May 9, 2026
Yitong Xin, Alan K. Davis, Susan Yoon et al.
Background and Purpose: Ayahuasca can produce a dynamic set of both positive and negative acute effects. Commonly reported challenges include physical symptoms (e.g., nausea, vomiting) and emotional distress (e.g., frightening hallucinations, paranoia). Despite these difficulties, many individuals describe their challenging experiences as contributing to personal healing and beneficial...
UvA-DARE
May 2, 2026
Wouter J. Hanegraaff
8 citations
in: Beatriz Caiuby Labate & Henrik Jungaberle (eds.), The Internationalization of Ayahuasca, Lit Verlag: Zürich / Berlin 2011, 85-103.
Human Psychopharmacology Clinical and Experimental
May 1, 2026
María Arqueros, J L Fayos Soler, Ausiàs Cebolla et al.
OBJECTIVE: 'Ego dissolution' refers to a temporary state characterized by diminished self-referential processing, which leads to a breakdown of personal boundaries and an enhanced sense of unity with the environment. Both psychedelics, such as ayahuasca, and contemplative practices, like meditation, have been proposed as mechanisms for modulating the ego. While ayahuasca induces transient...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
S Pack, T Ellett, J Pham et al.
Abstract Introduction Ayahuasca is a psychoactive brew used in Amazonian ceremonies, containing monoamine oxidase inhibitors (MAOIs) from Banisteriopsis caapi and N,N-dimethyltryptamine (DMT) from Psychotria viridis or Diplopterys cabrerana. Its global use has expanded for perceived antidepressant and anti-addictive effects. However, its MAOI content predisposes users to serotonergic toxicity...