American Journal of Respiratory and Critical Care Medicine
May 1, 2026
I Alvarez Orozco, H MarÍn Agudelo, J L Jurado et al.
Abstract Rationale Narcolepsy often includes highly disabling symptoms such as hypnagogic hallucinations and sleep paralysis, which significantly impair quality of life. Lucid dream therapy and imagery rehearsal techniques have shown efficacy in treating nightmares, but their application in narcolepsy remains underexplored. Objectives To evaluate the efficacy of lucid dream therapy and imagery...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
S Pack, Tyler R Ellett, Jamie Pham et al.
Abstract Introduction Ayahuasca is a psychoactive brew used in Amazonian ceremonies, containing monoamine oxidase inhibitors (MAOIs) from Banisteriopsis caapi and N,N-dimethyltryptamine (DMT) from Psychotria viridis or Diplopterys cabrerana. Its global use has expanded for perceived antidepressant and anti-addictive effects. However, its MAOI content predisposes users to serotonergic toxicity...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
R. Culver, A. Weiß, S. Batra
Nitrous oxide (N2O), historically called “laughing gas”, is a common inhalant used as a recreational hallucinogenic [1]. Patients with a history of habitual N2O use have been found to have prothrombotic complications, with deep vein thrombosis (DVT), pulmonary embolism (PE), or cerebral vascular injuries [1,2,3]. Chronic exposure to N2O disrupts folate dependent pathways by inactivating vitamin...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
W Griffin, S Frison-Roche, D S O’Callaghan
Abstract Introduction Chronic use of inhaled nitrous oxide (NO) or “laughing gas” inactivates vitamin B12 causing a functional B12 deficiency. Active B12 is a coenzyme for the conversion of methylmalonic acid to succinyl Co-A and homocysteine to methionine. These molecules are precursors for the synthesis and maintenance of myelin nerve sheaths. Therefore, functional B12 deficiency compromises...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
T. V. von Visger, Y. -. Chang
Pulmonary hypertension (PH) is a severe cardiopulmonary disease with pathophysiological abnormalities that result in high symptom burden, psychological distress (anxiety and depression), and difficulties in symptom self-management. A multi-model Mindfulness Meditation for Pulmonary Hypertension (MMPH) has been shown to reduce depression and PH symptoms in 15 community-dwelling adults with PH.1...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
L. Harper, M. Macmurdo, A. White et al.
Patients with sarcoidosis consistently identify fatigue as a primary driver of morbidity. Up to 70% experience severe fatigue that limits participation in household, social, and vocational activities, yet no effective therapy currently exists. Members of the Cleveland Clinic Sarcoidosis Community Advisory Board strongly advocated for wellness and lifestyle interventions to address fatigue. A...
American Journal of Respiratory and Critical Care Medicine
May 1, 2026
Louise Hecker, Jennifer Kleinhenz, Cristian Coarfa et al.
The elderly population is rapidly growing. Overwhelming epidemiologic data has demonstrated worse health outcomes with increasing age for a multitude of lung diseases (COVID being one of numerous examples). There is an increasingly urgent need for a more complete understanding of the molecular pathways and biological processes underlying aging to improve outcomes for age-associated lung...