Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
March 30, 2026
Darren M. Lipnicki, Meritxell Valenti, Elizabeth Lucia Valeriano‐Lorenzo et al.
1 citation
Abstract INTRODUCTION Dreaming is subserved by the default mode network (DMN) and can be abolished by focal lesions within key regions. DMN dysfunction is promoted by pre‐clinical Alzheimer's pathology and apolipoprotein E ( APOE ) ε4 carriage, but any effects of these on dreaming are unknown. METHODS Associations between dream recall and APOE ε4 carriage and blood phosphorylated tau (p‐tau)...
bioRxiv (Cold Spring Harbor Laboratory)
March 27, 2026
Morgan Rose Healey, Yaser Sanchez-Gama, Mengyuan Ding et al.
Abstract Self-transcendence, the reorientation of experience away from the self toward others, nature, or broader meaning, is a fundamental dimension of human psychology, yet its causal neural architecture remains poorly understood. Here we applied lesion network mapping to 88 neurosurgical patients with pre- and post-operative assessments of trait self-transcendence to identify the distributed...
Neuroimage
March 25, 2026
Enhanced default mode network stability in highly superior autobiographical memory.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
March 21, 2026
Claudio Agnorelli, Joseph Peill, Gabriela Sawicka et al.
We investigated ketamine's neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/kg, intravenous). Eleven male participants underwent two PET/MRI scans with [11C]-UCBJ (synaptic density/plasticity), 1H-MRS (glutamate and GABA) and...
Discover Mental Health
March 19, 2026
Àlvar Farré-colomés, Olga Rublinetska, Oscar Soto-Angona
Psilocybin-assisted therapies are innovative therapeutic approaches, particularly in the treatment of depression. However, there are sparse studies providing functional magnetic resonance imaging (fMRI) evidence elucidating the underlying biological mechanisms that support clinical outcomes. This review aims to comprehensively gather all the evidence reported in psilocybin studies using fMRI...
bioRxiv
March 17, 2026
From default to creativity: prefrontal and cerebellar contributions of the default mode network to goal-directed remote thinking
Preprints.org
March 17, 2026
Yuki Ueda
preprint
The nature of consciousness, specifically the state of "pure consciousness"—often characterized in contemplative traditions as a state of awareness devoid of intentional content—has transitioned from a topic of purely philosophical inquiry to a rigorous subject of neuroscientific study. This review synthesizes current clinical and neurobiological research to propose that oxytocin (OT), a...
BMC Complementary Medicine and Therapies
March 16, 2026
Xing-Chen Zhou, Shuang Wu, Kai-Zheng Wang et al.
OBJECTIVE: To analyze the brain functional network remodeling associated with the relief of negative emotions in patients with lumbar disc herniation (LDH) treated with lever positioning manipulation (LPM) using resting-state fMRI (rs-fMRI) technology. METHODS: A prospective study included LDH patients (Group 1, n = 47) and age- and gender-matched healthy controls (Group 2, n = 43). Group 1...
Behavioral Sciences
March 9, 2026
Luis Miguel Gallardo, Saamdu Chetri
3 citations
Hypnosis has traditionally been conceptualized as a clinical technique for reducing physiological symptoms (e.g., pain, nausea) and psychological symptoms (e.g., anxiety, intrusive thoughts), yet emerging neuroscientific evidence suggests it operates through the fundamental mechanisms of emotional regulation and self-integration. This integrative review synthesizes research on clinical hypnosis...
bioRxiv (Cold Spring Harbor Laboratory)
March 5, 2026
Venkatesh Subramani, Annalisa Pascarella, Jérémy Brunel et al.
Abstract Psychedelics profoundly alter conscious experience, yet how they reshape the relationship between brain anatomy and function remains unclear. In particular, it is unknown whether psychedelic states reflect a global disruption of structure–function organization or a frequency– and network-specific reconfiguration of neural dynamics relative to the structural connectome. Here we address...