LSD: No Teratogenic Action in Rats, Mice, and Hamsters
J. Serratrice, R Dupuis, Marie Christine Aubry
Science August 7, 1970 DOI: 10.1126/science.169.3945.588 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 187 |
| Population | Pregnant rats, mice, and hamsters |
| Intervention | Lysergic acid diethylamide tartrate |
| Dose | 5 to 500 micrograms per kilogram of body weight per day |
| Topics | LSD |
| Keywords | Hamster Abortifacient Gestation Fetus Endocrinology Tartrate Body weight Mesocricetus Teratology Pregnancy Physiology |
| Citations | 23 |
| Key findings | Lysergic acid diethylamide tartrate showed no abortifacient, teratogenic, or growth-depressing effects in the fetuses of rats, mice, and hamsters. |
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 5
- LSD and Genetic Damage Science April 30, 1971
- Possible Reproductive Detriment in LSD Users JAMA December 11, 1972
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
- The changing outlook of psychedelic drugs: The importance of risk assessment and occupational exposure limits Journal of Applied Toxicology August 30, 2023
Cites 4
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967
- Lysergic Acid Diethylamide (LSD): No Teratogenicity in Rats Science February 16, 1968
- Lysergic Acid Diethylamide: Effects on the Developing Mouse Lens Science May 2, 1969