LSD: No Teratogenic Action in Rats, Mice, and Hamsters
J. Serratrice, R Dupuis, Marie Christine Aubry
Science August 7, 1970 DOI: 10.1126/science.169.3945.588 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 187 |
| Population | Pregnant rats, mice, and hamsters |
| Intervention | Lysergic acid diethylamide tartrate |
| Dose | 5 to 500 micrograms per kilogram of body weight per day |
| Topics | LSD |
| Keywords | Hamster Abortifacient Gestation Fetus Endocrinology Tartrate Body weight Mesocricetus Teratology Pregnancy Physiology |
| Citations | 23 |
| Key findings | Lysergic acid diethylamide tartrate showed no abortifacient, teratogenic, or growth-depressing effects in the fetuses of rats, mice, and hamsters. |
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of body weight per day either at the beginning of gestation or during the period of organogenesis. Examination of the 1003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses obtained failed to prove any abortifacient, teratogenic, or growth-depressing effects.