LSD and Chromosomes
JAMA November 3, 1969 DOI: 10.1001/jama.1969.03160310037007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind controlled study Peer reviewed |
|---|---|
| Sample size | 37 |
| Population | Patients receiving LSD in psychotherapy and black-market LSD users |
| Intervention | LSD |
| Topics | LSD |
| Keywords | Double blind study |
| Citations | 55 |
| Key points | Pure LSD did not significantly increase chromosomal aberration rates in human lymphocytes in vivo. |
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, controlled research of the effects of the drug in psychotherapy and in five black-market LSD users who volunteered to take pure LSD in a research setting. Statistical analysis revealed no significant difference between the before- and after-LSD chromosomal aberration rates. In addition, a post-LSD study of eight normal subjects who had received LSD in previous research experiments was also performed with the same cytogenetic methods. The results of these experiments consistently supported the conclusion that at this time there is no definite evidence that pure LSD damages chromosomes of human lymphocytes in vivo as studied from 72-hour cultures.
Comparable studies
Other randomized controlled trials on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases Patients with anxiety associated with life-threatening diseases | 2014 | Randomized controlled trial | n = 12 |
| Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users | 1994 | Double-blind, saline placebo-controlled, randomized study | n = 12 |
| Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Healthy subjects (8 women, 8 men) | 2014 | Double-blind, randomized, placebo-controlled, crossover study | n = 16 |
| Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Healthy human participants | 2018 | Double-blind, randomized, counterbalanced, cross-over study | n = 24 |
| LSD-induced entropic brain activity predicts subsequent personality change. Healthy adults | 2016 | Balanced-order, placebo-controlled study | n = 19 |
Citations in the library
Cited by 13
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- The Experimental Use of Psychedelic (LSD) Psychotherapy JAMA June 15, 1970
- LSD and Genetic Damage Science April 30, 1971
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Effect of LSD on Human Pregnancy JAMA June 1, 1970
and 8 more in the library
Cites 11
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967
and 6 more in the library