Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat
Science May 21, 1976 DOI: 10.1126/science.192.4241.801 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD mescaline dimethyltryptamine cyproheptadine α-propyldopacetamide |
| Dose | 1 microgram per kilogram of body weight |
| Topics | LSD Mescaline Serotonin |
| Keywords | Licking Cyproheptadine Hallucinogen Pharmacology |
| Citations | 118 |
| Key findings | LSD and mescaline attenuate punishment-induced suppression of licking in rats, likely via decreased activity of serotonin-containing neurons. |
Abstract
At a dose as low as 1 microgram per kilogram of body weight, lysergic acid diethylamide (LSD) significantly decreased the suppressive effect of electric shock on licking behavior of the rat. Attenuation of punishment was also obtained with mescaline, but neither dimethyltryptamine nor Δ 9 -tetrahydrocannabinol was active in this test. Cyproheptadine and α-propyldopacetamide, drugs that interfere with the function of neurons that contain serotonin, have a behavioral effect similar to that of LSD and mescaline, which suggests that the attenuation of punishment produced by these hallucinogens may result from decreased activity of such neurons.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay | |
| Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys Rhesus monkeys with a history of MDMA self-administration | 2004 | Observational cohort | n = 4 |
Citations in the library
Cited by 9
- Anti-aversive role of serotonin in the dorsal periaqueductal grey matter. Psychopharmacology 1985
- Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines. Neuropharmacology October 1, 1982
- Effects of diazepam and of serotonin agonists on hyponeophagia in rats. Neuropharmacology April 1, 1982
- The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats Pharmacology, Biochemistry, and Behavior May 1, 1981
- Psilocybin: Biphasic dose-response effects on the acoustic startle reflex in the rat Pharmacology, Biochemistry, and Behavior April 1, 1977
and 4 more in the library
Cites 5
- Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science August 16, 1968
- Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide British Journal of Pharmacology September 1, 1968
- Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. Journal of Pharmacology and Experimental Therapeutics June 1, 1975
- Lysergic acid diethylamide: Role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine) Science 1969
- Effect of N,N-Dimethyltryptamine and D-Lysergic Acid Diethylamide on the Release of 5-Hydroxyindoles in Rat Forebrain Nature April 1, 1971