Chromosomal Damage in LSD Users
JAMA April 15, 1968 DOI: 10.1001/jama.1968.03140160024006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | LSD users and drug-free controls, and children exposed to LSD in utero |
| Topics | LSD |
| Keywords | Internet privacy Medical emergency |
| Citations | 59 |
| Key findings | LSD users and children exposed to the drug in utero have higher rates of chromosomal breakage, but the frequency of breaks does not correlate with dosage. |
Abstract
An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also found in children exposed to the drug in utero. The data showed no correlation between amount of drug per dose, number of doses, or total dosage and frequency of chromosomal breaks.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 15
- Adverse effects of psychedelics: From anecdotes and misinformation to systematic science. Journal of Psychopharmacology February 2, 2022
- The Experimental Use of Psychedelic (LSD) Psychotherapy JAMA June 15, 1970
- Clinical applications of hallucinogens: A review. Experimental and Clinical Psychopharmacology August 1, 2016
- LSD and Chromosomes JAMA November 3, 1969
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
and 10 more in the library
Cites 9
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967
and 4 more in the library