ISSN 1538-3598
61 papers in the library · 4,588 citations · publishing 1960-2026
JAMA December 14, 1979 Bruce Greyson 1 citation
In Reply.— Two reasons justify the publication of our article in a medical journal. First, the experiences to which we drew attention occur frequently (although not exclusively) during grave physical illnesses and injuries. The actual role of physiological changes in these experiences is still poorly understood. Some persons have them when they think they are going to die, even though they are...
JAMA August 8, 1977 Sidney Cohen 31 citations
PHENCYCLIDINE hydrochloride (Sernylan) was investigated during the 1950s as an anesthetic agent. Although it was found to be effective for analgesia and anesthesia, certain side effects, especially postoperative agitation and delirium that lasts for hours, precluded its final acceptance. Later, phencyclidine was discovered to be a satisfactory anesthetic agent for certain animals, and is...
JAMA August 2, 1976 R K Siegel
Herbal preparations, designed to be smoked or ingested for "health and happiness", are promoted as legal hallucinogens, euphoriants, and marihuana substitutes. A total of 25 psychoactive substances have been identified in these products, and a number of intoxications have resulted from their short- or long-term use. Physicians should be alerted to the nature of these effects when taking drug...
JAMA November 3, 1975 C B Liden, F H Lovejoy, C E Costello
In nine cases of phencyclidine hydrochloride poisoning, early signs of overdose included drowsiness, nystagmus, miotic pupils, blood pressure elevation, increased deep tendon reflexes, ataxia, anxiety, and agitation. In more severe cases, seizures, spasticity, and opisthotonos were seen in addition to deep coma and respiratory depression. Treatment included removal by emetics or lavage,...
JAMA October 20, 1975 David Dorrance 20 citations
Fify-seven Huichol Indians with a lifelong individual history and a 1,600-year cultural tradition of ingestion of peyote, a mescaline-containing cactus possessing hallucinogenic properties, were compared with 50 Huichol Indian controls and ten laboratory controls for effects on lymphocyte chromosomes. The frequency of abnormalities in the experimental and control groups did not differ...
JAMA October 20, 1975 Arthur D. Bloom 4 citations
Given the controversy of the late 1960s and early 1970s over the possible induction of chromosomal damage by psycho-active agents like LSD and marihuana, the peyote study of Teplitz et al (p 299), is reassuring. It is, first of all, comforting to know that in vivo studies of agents that are possible chromosomal mutagens can produce, when properly designed and executed, clear-cut results....
JAMA October 20, 1975 A. D. Bloom 1 citation
Given the controversy of the late 1960s and early 1970s over the possible induction of chromosomal damage by psycho-active agents like LSD and marihuana, the peyote study of Teplitz et al (p 299), is reassuring. It is, first of all, comforting to know that in vivo studies of agents that are possible chromosomal mutagens can produce, when properly designed and executed, clear-cut results....
JAMA November 11, 1974 Miles K. Crowder 16 citations
To the Editor.— In a recent issue (229:763, 1974), Shaffer describes a series of cases characterized by anesthesia, analgesia, nystagmus, dizziness, diplopia, visual distortions, and psychosis. These findings were attributed to ketamine, a derivative of phencyclidine. Phencyclidine is a major component of street drug preparations.1In one series, phencyclidine was detected in 184 of 237 street...
JAMA December 11, 1972 Cecil B. Jacobson 52 citations
One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of...
JAMA February 14, 1972 Peter Reich 41 citations
A 22-year-old student killed a stranger during a psychotic reaction precipitated by lysergic acid diethylamide. With the exception of another bad trip, he had not been psychotic previously and showed no evidence of psychosis during four years of follow-up treatment.
JAMA November 15, 1971 Barry I. Liskow 6 citations
To the Editor.— Friedman and Hirsch's article, "Extreme Hyperthermia after LSD Ingestion," (217:1549-1550, 1971) should be interpreted with caution. The case report of a hyperactive, verbally unresponsive patient with mildly elevated blood pressure, increased heart rate, and slightly dilated and reactive pupils is consistent with amphetamine as well as LSD overdose. The amnesia for the episode...
JAMA September 13, 1971 Steven A. Friedman 37 citations
Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hyperthermia (106.4 F [41.3 C] axillary) in man, following the use of LSD, and may have been dose-related. The hyperthermia was rapidly reversed by alcoholic-ice soaks, hallucinations ended about 18 hours later, and the patient recovered without obvious...
JAMA June 15, 1970 Walter N. Pahnke 214 citations
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the wave of excitement among experimentalists in the 1950s when it was claimed that lysergic acid diethylamide (LSD) could produce a model psychosis which might be useful in understanding schizophrenia. While this promise was fading, enthusiastic...
JAMA June 15, 1970 W. N. Pahnke 41 citations
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the wave of excitement among experimentalists in the 1950s when it was claimed that lysergic acid diethylamide (LSD) could produce a model psychosis which might be useful in understanding schizophrenia. While this promise was fading, enthusiastic...
JAMA June 1, 1970 William H. Mcglothlin 40 citations
The frequencies of spontaneous abortions, premature births, and birth defects in 121 human pregnancies following relatively infrequent, low doses of medically administered lysergic acid diethylamide are within the normal ranges. The incidence of spontaneous abortions was above average for a small sample of 27 pregnancies where LSD was ingested under both medical and nonmedical conditions....
JAMA February 9, 1970 Lillian Y. F. Hsu 33 citations
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement....
JAMA November 3, 1969 Joe‐hin Tjio 55 citations
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, controlled research of the effects of the drug in psychotherapy and in five black-market LSD users who volunteered to take pure LSD in a research setting. Statistical analysis revealed no significant difference between the before- and after-LSD...
JAMA November 3, 1969 J. H. Tjio 15 citations
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, controlled research of the effects of the drug in psychotherapy and in five black-market LSD users who volunteered to take pure LSD in a research setting. Statistical analysis revealed no significant difference between the before- and after-LSD...
JAMA September 1, 1969 Fred Charatan
To the Editor:— I was interested in Dr. Schneck's excellent article on Henry Fuseli (207:725, 1969). "The Nightmare" is, of course, his best known work. Dr. Schneck has argued convincingly that "The Nightmare" represents the well-known clinical syndrome of sleep paralysis. Critics of Fuseli's work, eg, Sacheverell Sitwell, have also commented on the quality of "static horror" that they project....
JAMA December 2, 1968 David A. Hungerford 40 citations
Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberration frequencies prior to therapy were established for three of the four patients; these were comparable to frequencies in control subjects. Following each of three doses given intravenously (usually 200μg per dose), each patient's chromosomes were...
JAMA September 9, 1968 Lionel Grossbard 23 citations
Acute leukemia occurred in a user of several hallucinogenic drugs (lysergic acid diethylamide [LSD], mescaline, marihuana, and amphetamines). The leukemic leukocytes of the patient contained a Ph1-like chromosome; lymphocytes transformed with phytohemagglutinin did not show chromosome breaks. A Ph1-like chromosome has only rarely been reported in either acute leukemia or in cultured lymphocytes...
JAMA April 15, 1968 José Egozcue 59 citations
An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also found in children exposed to the drug in utero. The data showed no correlation between amount of drug per dose, number of doses, or total dosage and frequency of chromosomal breaks.
JAMA April 15, 1968 Joseph N. Digiacomo 18 citations
Four cases of stramonium poisoning in teen-agers secondary to ingestion of Asthmador asthmatic powder (stramonium-belladonna mixture) presented as LSD reactions. The clinical manifestations were acute brain syndrome and physical signs of atropinization. The effects of stramonium ingestion are similar to the effects of the ingestion of amphetamine and LSD, but in addition to the psychosis due to...
JAMA February 26, 1968 Charles Savage 8 citations
LSD is the only new treatment for alcoholism which has been introduced in recent years; on that basis the authors justify this latest volume on LSD therapy. It gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds...
JAMA September 11, 1967 Doris H. Milman 18 citations
A 5-year-old girl with an apparently normal premorbid personality and adjustment became acutely psychotic following a single accidental ingestion of 100μg of d-lysergic acid diethylamide (LSD), with agitation, panic, depression and flattening of affect, disorientation, feelings of depersonalization, distortion of body image, and depression of intellectual functioning. In addition she displayed...