Effect of Peyote on Human Chromosomes
JAMA October 20, 1975 DOI: 10.1001/jama.1975.03260160047012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 117 |
| Population | Huichol Indians with lifelong peyote ingestion, Huichol Indian controls, and laboratory controls |
| Topics | Mescaline |
| Keywords | Ingestion Lymphocyte Traditional medicine Physiology |
| Citations | 20 |
| Key findings | Multigenerational ingestion of peyote is not associated with abnormalities in lymphocyte chromosomes. |
Abstract
Fify-seven Huichol Indians with a lifelong individual history and a 1,600-year cultural tradition of ingestion of peyote, a mescaline-containing cactus possessing hallucinogenic properties, were compared with 50 Huichol Indian controls and ten laboratory controls for effects on lymphocyte chromosomes. The frequency of abnormalities in the experimental and control groups did not differ significantly. Our results indicate that multigenerational ingestion of peyote is not associated with abnormalities in lymphocyte chromosomes.
Comparable studies
Other observational and cohort studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Long-lasting subjective effects of LSD in normal subjects Healthy participants | 2017 | Observational cohort | n = 16 |
| Psychological and cognitive effects of long-term peyote use among Native Americans. Navajo Native Americans aged 18-45 | 2005 | Observational cohort | n = 176 |
| Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Normal men who were volunteers | 1992 | Observational cohort | n = 12 |
| 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug Normal control volunteers | 1967 | Observational study |