Chromosome Abnormality in Offspring of LSD User
JAMA February 9, 1970 DOI: 10.1001/jama.1970.03170060051010 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Newborn girl with trisomy 13 |
| Topics | LSD |
| Keywords | Offspring Trisomy Chromosomal translocation Pregnancy Chromosomal rearrangement Chromosome Abnormality Genetics Buthidae Karyotype Andrology |
| Citations | 33 |
| Key findings | Lysergic acid diethylamide use prior to conception may have induced chromosomal rearrangement leading to trisomy 13 in the offspring. |
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.